Fragment-based methods for identifying lead compounds are a promising alternative to traditional drug discovery approaches.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Card et al., Nat. Biotechnol. 23, 201–207 (2005).
Campbell, S.F. Clin. Sci., 99, 255–260 (2000).
Erlanson, D.A., McDowell, R.S. & O'Brien, T. J. Med. Chem. 47, 3463–82 (2004).
Mehats, C., Andersen, C.B., Filopanti, M., Jin S.-L.C. & Conti, M. Trends Endocrinol. Metab. 13, 29–35 (2002).
Rotella, D.P. Nat. Rev. Drug Discov. 1, 674–82 (2002).
Rees, D.C., Congreve, M., Murray, C.W. & Carr, R. Nat. Rev. Drug Discov. 3, 660–672 (2004).
Shuker, S.B., Hajduk, P.J., Meadows, R.P. & Fesik, S.W. Science 274, 1531–1534 (1996).
Nienaber, V.L. et al. Nat. Biotechnol. 18, 1105–1108 (2000).
Blundell, T.L., Jhoti, H. & Abell, C. Nat. Rev. Drug Discov. 1, 45–54 (2002).
Hopkins, A.L, Groom, C. R & Alex, A. Drug Discov. Today 9, 430–431 (2004).
Hann, M.M., Leach, A.R. & Harper, G. J. Chem. Inf. Comput. Sci. 41, 856–864 (2001).
Congreve, M., Carr, R., Murray, C. & Jhoti, H. Drug Disc. Today 8, 876–877 (2003).
Hartshorn, M.J. et al. J. Med. Chem. 21 December 2005, 48, DOI: 10.1021/jm0495778.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Jhoti, H. A new school for screening. Nat Biotechnol 23, 184–186 (2005). https://doi.org/10.1038/nbt0205-184
Issue Date:
DOI: https://doi.org/10.1038/nbt0205-184