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Dicing with siRNA

Nature Biotechnology volume 23, pages 181–182 (2005)Cite this article

Two new studies describe strategies for increasing the efficiency of RNA interference.

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Figure 1: Synthetic RNA duplexes consisting of either 27-mer blunt or short hairpin (sh) RNAs with 29-bp stems and 2-nt 3′ overhangs are more potent inducers of RNA interference than conventional 21-mer siRNAs, providing long-lasting silencing and maximal inhibition of gene expression at lower concentrations.

Bob Crimi

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  1. Department of Cancer Biology, Cleveland Clinic Foundation, NB40 The Lerner Research Institute, 9500 Euclid Avenue, Cleveland, 44195, Ohio, USA

    Bryan R.G. Williams

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  1. Bryan R.G. Williams
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Williams, B. Dicing with siRNA. Nat Biotechnol 23, 181–182 (2005). https://doi.org/10.1038/nbt0205-181

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