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Trends in the Development of Baculovirus Expression Vectors

Bio/Technology volume 6, pages 47–55 (1988)Cite this article

Abstract

We describe the current status and potential use of baculovirus vectors for the expression of foreign genes in insect cells. Trends in the development of transfer vectors for the expression of foreign genes under the control of the strong polyhedrin promoter of Autographa californica nuclear polyhedrosis virus and strategies for maximizing levels of expression are discussed. Baculovirus vectors have achieved widespread acceptance for their ability to express proteins of agricultural and medical importance. A baculovirus vector was used to express the first recombinant HIV envelope proteins to receive F.D.A. approval for clinical evaluation as a candidate vaccine for AIDS. These insect DNA virus vectors are contributing to understanding the molecular biology of gene and protein function and regulation in both vertebrate and insect systems.

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  1. Max D. Summers: Corresponding author.

Authors and Affiliations

  1. Department of Entomology, Texas A&M University and Texas Agricultural Experiment Station, College Station, Texas, 77843-2475

    Verne A. Luckow & Max D. Summers

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Luckow, V., Summers, M. Trends in the Development of Baculovirus Expression Vectors. Nat Biotechnol 6, 47–55 (1988). https://doi.org/10.1038/nbt0188-47

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