Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Cancer immunotherapy

Dendritic-cell vaccines on the move

Vaccines that induce an antitumour immune response are disappointingly ineffective in treating patients with cancer. Pre-conditioning the vaccination site to induce inflammation might provide a way to improve this therapy. See Letter p.366

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Optimizing dendritic-cell vaccines.

Notes

  1. See all news & views

References

  1. Sabado, R. L. & Bhardwaj, N. Ann. NY Acad. Sci. 1284, 31–45 (2013).

    Article  ADS  CAS  Google Scholar 

  2. Mitchell, D. A. et al. Nature 519, 366–369 (2015).

    Article  ADS  CAS  Google Scholar 

  3. Palucka, K. & Banchereau, J. Immunity 39, 38–48 (2013).

    Article  CAS  Google Scholar 

  4. Kantoff, P. W. et al. N. Engl. J. Med. 363, 411–422 (2010).

    Article  CAS  Google Scholar 

  5. Allan, R. S. et al. Immunity 25, 153–162 (2006).

    Article  CAS  Google Scholar 

  6. de Vries, I. J. M. et al. Cancer Res. 63, 12–17 (2003).

    CAS  PubMed  Google Scholar 

  7. Martín-Fontecha, A. et al. J. Exp. Med. 198, 615–621 (2003).

    Article  Google Scholar 

  8. Sallusto, F. & Lanzavecchia, A. Immunol Rev. 177, 134–140 (2000).

    Article  CAS  Google Scholar 

  9. Griffith, J. W., Sokol, C. L. & Luster, A. D. Annu. Rev. Immunol. 32, 659–702 (2014).

    Article  CAS  Google Scholar 

  10. Luther, S. A. & Cyster, J. G. Nature Immunol. 2, 102–107 (2001).

    Article  CAS  Google Scholar 

  11. Menten, P., Wuyts, A. & Van Damme, J. Cytokine Growth Factor Rev. 13, 455–481 (2002).

    Article  CAS  Google Scholar 

  12. Morlacchi, S. et al. J. Immunol. 186, 6807–6814 (2011).

    Article  CAS  Google Scholar 

  13. Nair, S. K., Sampson, J. H. & Mitchell, D. A. OncoImmunology 3, e29289 (2014).

    Article  Google Scholar 

  14. Ridolfi, L. et al. J. Transl. Med. 11, 135 (2013).

    Article  CAS  Google Scholar 

  15. Bogunovic, D. et al. Cancer Res. 71, 5467–5476 (2011).

    Article  CAS  Google Scholar 

  16. Ribas, A. et al. Clin. Cancer Res. 15, 6267–6276 (2009).

    Article  CAS  Google Scholar 

  17. Vera, M. et al. Mol. Ther. 12, 950–959 (2005).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Nina Bhardwaj.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Sabado, R., Bhardwaj, N. Dendritic-cell vaccines on the move. Nature 519, 300–301 (2015). https://doi.org/10.1038/nature14211

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nature14211

This article is cited by

Search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer