Host-cell detection of lipopolysaccharide in the outer membrane of Gram-negative bacteria was thought to be restricted to the cell-surface receptor TLR4. It emerges that lipopolysaccharide can also be sensed in the cytoplasm.
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*This News & Views article was published online on 4 September 2013.
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Rathinam, V., Fitzgerald, K. Lipopolysaccharide sensing on the inside. Nature 501, 173–175 (2013). https://doi.org/10.1038/nature12556
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DOI: https://doi.org/10.1038/nature12556
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