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Immunology

Lipopolysaccharide sensing on the inside

Host-cell detection of lipopolysaccharide in the outer membrane of Gram-negative bacteria was thought to be restricted to the cell-surface receptor TLR4. It emerges that lipopolysaccharide can also be sensed in the cytoplasm.

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Figure 1: Inflammasome activation by caspase-11.

Notes

  1. *This News & Views article was published online on 4 September 2013.

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Correspondence to Katherine A. Fitzgerald.

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Rathinam, V., Fitzgerald, K. Lipopolysaccharide sensing on the inside. Nature 501, 173–175 (2013). https://doi.org/10.1038/nature12556

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