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Heparan sulphate proteoglycans fine-tune mammalian physiology

Nature volume 446, pages 1030–1037 (2007)Cite this article

Abstract

Heparan sulphate proteoglycans reside on the plasma membrane of all animal cells studied so far and are a major component of extracellular matrices. Studies of model organisms and human diseases have demonstrated their importance in development and normal physiology. A recurrent theme is the electrostatic interaction of the heparan sulphate chains with protein ligands, which affects metabolism, transport, information transfer, support and regulation in all organ systems. The importance of these interactions is exemplified by phenotypic studies of mice and humans bearing mutations in the core proteins or the biosynthetic enzymes responsible for assembling the heparan sulphate chains.

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Figure 1: Assembly of heparan sulphate and formation of binding sites for ligands.
Figure 2: Heparan sulphate proteoglycans have many roles in cell physiology.

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Acknowledgements

We thank S. Olson for careful reading of this manuscript and for many helpful suggestions. M.S. and J.D.E. are affiliated with the Biomedical Sciences Graduate Program at University of California, San Diego. This work was supported by grants (J.D.E.) and a training grant (M.S.) from the National Institutes of Health.

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  1. Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, 92093, California, USA

    Joseph R. Bishop, Manuela Schuksz & Jeffrey D. Esko

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Bishop, J., Schuksz, M. & Esko, J. Heparan sulphate proteoglycans fine-tune mammalian physiology. Nature 446, 1030–1037 (2007). https://doi.org/10.1038/nature05817

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