Abstract
Because arsenic (As) and manganese (Mn) are able to pass the placenta, infants among exposed populations may be exposed to considerable levels in utero. The main objective of this paper is to evaluate infant toenails, hair, and cord blood as biomarkers of prenatal exposure to As and Mn and determine the relationship between maternal and infant As and Mn concentrations in these biomarkers. Of the 1196 pregnant women in Bangladesh who were monitored throughout pregnancy until 1 month post-partum and completed all study visits, we included 711 mother–infant pairs who had at least one maternal and one infant biomarker of exposure available for analysis. Toenail and hair samples were collected from the women during the first trimester and 1 month post-partum and from the infants at the age of 1 month. Cord blood was collected at the time of delivery. Maternal toenail concentrations were correlated with infant toenail concentrations for As and Mn (n=258, r=0.52, 95% CI: 0.43–0.60, P<0.0001 and r=0.39, 95% CI: 0.28–0.49, P<0.0001), respectively. Similarly, maternal hair concentrations were correlated with infant hair As (n=685, r=0.61, 95% CI: 0.56–0.65, P<0.0001) and infant hair Mn (n=686, r=0.21, 95% CI: 0.14–0.28, P<0.0001). Cord blood As was correlated with infant toenail and hair As, although cord blood Mn was only correlated with infant toenail. Toenails and cord blood appear to be valid biomarkers of maternal–fetal transfer of As and Mn, whereas hair may not be a suitable biomarker for in utero exposure to Mn.
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References
Mukherjee A, Sengupta MK, Hossain MA, Ahamed S, Das B, Nayak B et al. Arsenic contamination in groundwater: a global perspective with emphasis on the Asian scenario. J Health Popul Nutr 2006; 24: 142–163.
Sengupta MK, Mukherjee A, Hossain MA, Ahamed S, Rahman MM, Lodh D et al. Groundwater arsenic contamination in the Ganga-Padma-Meghna-Brahmaputra plain of India and Bangladesh. Arch Environ Health 2003; 58: 701–702.
(WHO) WHO. Guidelines for Drinking-water Quality, 2011.
Hasan S, Ali MA . Occurence of manganese in groundwater of Bangladesh and its implications on safe water supply. Journal of Civil Engineering 2010; 32: 121–128.
Wasserman GA, Liu X, Parvez F, Ahsan H, Factor-Litvak P, Kline J et al. Water arsenic exposure and intellectual function in 6-year-old children in Araihazar, Bangladesh. Environ Health Perspect 2007; 115: 285–289.
Wasserman GA, Liu X, Parvez F, Ahsan H, Factor-Litvak P, van Geen A et al. Water arsenic exposure and children's intellectual function in Araihazar, Bangladesh. Environ Health Perspect 2004; 112: 1329–1333.
Hafeman D, Factor-Litvak P, Cheng Z, van Geen A, Ahsan H . Association between manganese exposure through drinking water and infant mortality in Bangladesh. Environ Health Perspect 2007; 115: 1107–1112.
Khan K, Wasserman GA, Liu X, Ahmed E, Parvez F, Slavkovich V et al. Manganese exposure from drinking water and children's academic achievement. Neurotoxicology 2012; 33: 91–97.
Khan K, Factor-Litvak P, Wasserman GA, Liu X, Ahmed E, Parvez F et al. Manganese exposure from drinking water and children's classroom behavior in Bangladesh. Environ Health Perspect 2011; 119: 1501–1506.
Guan H, Wang M, Li X, Piao F, Li Q, Xu L et al. Manganese concentrations in maternal and umbilical cord blood: related to birth size and environmental factors. Eur J Public Health 2014; 24: 150–157.
Hall M, Gamble M, Slavkovich V, Liu X, Levy D, Cheng Z et al. Determinants of arsenic metabolism: blood arsenic metabolites, plasma folate, cobalamin, and homocysteine concentrations in maternal-newborn pairs. Environ Health Perspect 2007; 115: 1503–1509.
Guan H, Piao F, Zhang X, Li X, Li Q, Xu L et al. Prenatal exposure to arsenic and its effects on fetal development in the general population of Dalian. Biol Trace Elem Res 2012; 149: 10–15.
Krachler M, Rossipal E, Micetic-Turk D . Trace element transfer from the mother to the newborn—investigations on triplets of colostrum, maternal and umbilical cord sera. Eur J Clin Nutr 1999; 53: 486–494.
Zota AR, Ettinger AS, Bouchard M, Amarasiriwardena CJ, Schwartz J, Hu H et al. Maternal blood manganese levels and infant birth weight. Epidemiology 2009; 20: 367–373.
Osada H, Watanabe Y, Nishimura Y, Yukawa M, Seki K, Sekiya S . Profile of trace element concentrations in the feto-placental unit in relation to fetal growth. Acta Obstet Gynecol Scand 2002; 81: 931–937.
Concha G, Vogler G, Lezcano D, Nermell B, Vahter M . Exposure to inorganic arsenic metabolites during early human development. Toxicol Sci 1998; 44: 185–190.
Lin CC, Chen YC, Su FC, Lin CM, Liao HF, Hwang YH et al. In utero exposure to environmental lead and manganese and neurodevelopment at 2 years of age. Environ Res 2013; 123: 52–57.
Parajuli RP, Fujiwara T, Umezaki M, Watanabe C . Association of cord blood levels of lead, arsenic, and zinc with neurodevelopmental indicators in newborns: a birth cohort study in Chitwan Valley, Nepal. Environ Res 2013; 121: 45–51.
Hopps HC . The biologic bases for using hair and nail for analyses of trace elements. Sci Total Environ 1977; 7: 71–89.
He K . Trace elements in nails as biomarkers in clinical research. Eur J Clin Invest 2011; 41: 98–102.
Rakib MA, Huda ME, Hossain SM, Naher K, Khan R, Sultana MS et al. Arsenic content in inactive tissue: human hair and nail. J Sci Res Rep 2013; 2: 522–535.
Davis MA, Li Z, Gilbert-Diamond D, Mackenzie TA, Cottingham KL, Jackson BP et al. Infant toenails as a biomarker of in utero arsenic exposure. J Expo Sci Environ Epidemiol 2014; 24: 467–473.
Eastman RR, Jursa TP, Benedetti C, Lucchini RG, Smith DR . Hair as a biomarker of environmental manganese exposure. Environ Sci Technol 2013; 47: 1629–1637.
Mora AM, van Wendel de Joode B, Mergler D, Cordoba L, Cano C, Quesada R et al. Blood and hair manganese concentrations in pregnant women from the infants' environmental health study (ISA) in Costa Rica. Environ Sci Technol 2014; 48: 3467–3476.
Savabieasfahani M, Hoseiny M, Goodarzi S . Toxic and essential trace metals in first baby haircuts and mother hair from Imam Hossein Hospital Tehran, Iran. Bull Environ Contam Toxicol 2012; 88: 140–144.
Kile ML, Rodrigues EG, Mazumdar M, Dobson CB, Diao N, Golam M et al. A prospective cohort study of the association between drinking water arsenic exposure and self-reported maternal health symptoms during pregnancy in Bangladesh. Environ Health 2014; 13: 29.
Chen KL, Amarasiriwardena CJ, Christiani DC . Determination of total arsenic concentrations in nails by inductively coupled plasma mass spectrometry. Biol Trace Elem Res 1999; 67: 109–125.
Mandal BK, Ogra Y, Suzuki KT . Speciation of arsenic in human nail and hair from arsenic-affected area by HPLC-inductively coupled argon plasma mass spectrometry. Toxicol Appl Pharmacol 2003; 189: 73–83.
Takser L, Lafond J, Bouchard M, St-Amour G, Mergler D . Manganese levels during pregnancy and at birth: relation to environmental factors and smoking in a Southwest Quebec population. Environ Res 2004; 95: 119–125.
Aschner JL, Aschner M . Nutritional aspects of manganese homeostasis. Mol Aspects Med 2005; 26: 353–362.
Ljung KS, Kippler MJ, Goessler W, Grander GM, Nermell BM, Vahter ME . Maternal and early life exposure to manganese in rural Bangladesh. Environ Sci Technol 2009; 43: 2595–2601.
Gil F, Hernandez AF, Marquez C, Femia P, Olmedo P, Lopez-Guarnido O et al. Biomonitorization of cadmium, chromium, manganese, nickel and lead in whole blood, urine, axillary hair and saliva in an occupationally exposed population. Sci Total Environ 2011; 409: 1172–1180.
Kondakis XG, Makris N, Leotsinidis M, Prinou M, Papapetropoulos T . Possible health effects of high manganese concentration in drinking water. Arch Environ Health 1989; 44: 175–178.
Kaneshige E . Serum ferritin as an assessment of iron stores and other hematologic parameters during pregnancy. Obstet Gynecol 1981; 57: 238–242.
WebMD. Ferritin [updated August 6, 2012; cited 2015 May 13, 2015]. Available from http://www.webmd.com/a-to-z-guides/ferritin?page=2.
Viana GF, de Carvalho CF, Nunes LS, Rodrigues JL, Ribeiro NS, de Almeida DA et al. Noninvasive biomarkers of manganese exposure and neuropsychological effects in environmentally exposed adults in Brazil. Toxicol Lett 2014; 231: 169–178.
Acknowledgements
We acknowledge the contributions from Li Su, Nicola Lupoli, Ivan Pantic, Shangzhi Gao, Jongeun Rhee, Pi-I (Debby) Lin, Sakila (Joya) Afroz, and Hafiza (Suchanda) Sultana. This work was supported by grants from the US National Institute of Environmental Health Sciences (R01ES015533 and T42OH008416).
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Rodrigues, E., Kile, M., Dobson, C. et al. Maternal–infant biomarkers of prenatal exposure to arsenic and manganese. J Expo Sci Environ Epidemiol 25, 639–648 (2015). https://doi.org/10.1038/jes.2015.45
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DOI: https://doi.org/10.1038/jes.2015.45
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