Abstract
In the course of a screening for cytotoxic compounds from fungi four new terpenoid metabolites, named dasyscyphins A, B, C, and niveulone were isolated from fermentations of Dasyscyphus niveus strain A0101. While dasyscyphin A (1) exhibited no significant biological activities in our test systems dasyscyphin B (2) and dasyscyphin C (3) showed cytotoxic activities against human (HepG2, Hela S3, U937, Colo-320, Jurkat) cell lines with IC50-values of 0.5˜3 µg/ml while the activity of niveulone (4) was less pronounced. Only modest or weak antibiotic properties were observed for (2) and (3).
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Mierau, V., Rojas de La Parra, V., Sterner, O. et al. The Dasyscyphins A˜C and Niveulone, New Biologically Active Compounds from the Ascomycete Dasyscyphus niveus. J Antibiot 59, 53–56 (2006). https://doi.org/10.1038/ja.2006.8
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DOI: https://doi.org/10.1038/ja.2006.8
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The Journal of Antibiotics (2006)