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A heritable, non-genetic road to cancer evolution

Treatment for leukaemia can fail for reasons that are not fully clear. Tracking the progress of individual cellular lineages for this type of cancer offers a way to investigate this phenomenon.
  1. Tamara Prieto

    1. Tamara Prieto is in the New York Genome Center, New York, New York 10013, USA, and at Weill Cornell Medicine, New York.

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  2. Dan A. Landau

    1. Dan A. Landau is in the New York Genome Center, New York, New York 10013, USA, and at Weill Cornell Medicine, New York.

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The complexity of a tumour’s evolving cellular population poses an obstacle to successful therapy. Writing in Nature, Fennell et al.1 present data that pinpoint some of the mechanisms underlying the ability of cancers to evolve to a more aggressive and treatment-resistant form.

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Nature 601, 31-32 (2022)

doi: https://doi.org/10.1038/d41586-021-03606-z

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Competing Interests

The authors declare no competing interests.

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