Nature Immunology
2, 669 - 670 (2001)
doi:10.1038/90601
TCR avidity: it's not how strong you make it, it's how you make it strongDavid H. Margulies
Molecular Biology Section, Laboratory of Immunology, NIAID, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892-1892, USA. (dhm@nih.gov) Unlike the BCR, the TCR cannot undergo affinity maturation. However, T cells respond with greater sensitivity to antigen during an immune response. New evidence suggests T cells undergo avidity maturation to enhance T cell responsiveness in the absence of changes in intrinsic affinity.
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