Nature Genetics
27, 9 - 10 (2001)
doi:10.1038/83825
Methylation meets genomicsAndrew P Feinberg
Institute of Genetic Medicine, Johns Hopkins University
School of Medicine, 720 Rutland Avenue, Baltimore
, Maryland 21205, USA.
afeinberg@jhu.edu
The methylome—a neologism that describes the complete set
of DNA methylation modifications of a cell—has its own life cycle, and
alterations in the methylome may be linked to aging and cancer, as well as
polymorphic variation in populations. A study of the methylome in embryonic
fibroblasts further underscores the potent effect of p53 expression.
|
