The first structural analysis of part of the spinal muscular atrophy (SMA)-causing 'survival of motor neurons' (SMN) protein reveals a structural similarity to the common spliceosomal small nuclear ribonucleoprotein (snRNP) Sm proteins. This observation gives clues to possible SMN roles in the cell, the loss of which may contribute to the pathogenesis of SMA.
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MacKenzie, A., Gendron, N. Tudor reign. Nat Struct Mol Biol 8, 13–15 (2001). https://doi.org/10.1038/82983
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DOI: https://doi.org/10.1038/82983
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