Once natural killer cells identify their targets they engage their lysis machinery. Spontaneous, unlike antibody-dependent, cytotoxicity predominantly uses a Ras-independent pathway to accomplish this activation.
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Perussia, B. Signaling for cytotoxicity. Nat Immunol 1, 372–374 (2000). https://doi.org/10.1038/80808
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DOI: https://doi.org/10.1038/80808
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