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Transcriptional regulation of cellular transformation

Structurally and functionally altered transcription factors have been associated with many human neoplasms. A better understanding of these transcriptional defects has revealed new therapeutic opportunities.

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Figure 1: Mechanisms by which chimeric transcription factors can lead to cellular transformation.

Bob Crimi

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Salomoni, P., Pandolfi, P. Transcriptional regulation of cellular transformation. Nat Med 6, 742–744 (2000). https://doi.org/10.1038/77459

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