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Genetic testing and quality control in diagnostic laboratories

Nature Genetics volume 25, pages 259–260 (2000)Cite this article

Abstract

To evaluate the quality of genetic testing for cystic fibrosis, 136, 145 and 159 laboratories participated in a European study in 1996, 1997 and 1998, respectively. We sent six purified DNA samples carrying the more common CFTR mutations with the request to test them using routine protocols. A panel of experts reviewed the results together with the raw data.

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Acknowledgements

We thank M. Goossens, P.F. Pignatti, M. Stuhrmann, X. Estivill and R. Mountford for help in the distribution of samples; M. Schwartz and H. Scheffer for help in the QA scheme evaluation; and all the participating laboratories. This work was performed within the framework of the European Concerted Action on Cystic Fibrosis (Biomed-2, contract number BMH4-CT96-0462).

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Authors and Affiliations

  1. Center for Human Genetics, University of Leuven, Leuven, Belgium

    Elisabeth Dequeker & Jean-Jacques Cassiman

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  1. Elisabeth Dequeker
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  2. Jean-Jacques Cassiman
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Correspondence to Elisabeth Dequeker.

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Dequeker, E., Cassiman, JJ. Genetic testing and quality control in diagnostic laboratories. Nat Genet 25, 259–260 (2000). https://doi.org/10.1038/77008

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