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Nature Structural Biology  6, 301 - 304 (1999)
doi:10.1038/7529

Switching affinities in nuclear trafficking

Murray Stewart & Daniela Rhodes

Murray Stewart and Daniela Rhodes are at the MRC Laboratory of Molecular Biology, Hills Rd., Cambridge CB2 2QH, UK.

Correspondence should be addressed to Murray Stewart ms@mrc-lmb.cam.ac.uk or Daniela Rhodes rhodes@mrc-lmb.cam.ac.uk
A new structure of full length importin alpha, a key protein in the nuclear transport process, lends support to a model of autoinhibition mediated by importin alpha residues that mimic a nuclear localization sequence. This model explains the change in importin alpha affinity for nuclear localization sequences that occurs in transporting cargo from the cytoplasm to the nucleus.

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Nature Structural & Molecular Biology
ISSN: 1545-9993
EISSN: 1545-9985
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