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Alzheimer's disease

A protective mutation

Nature volume 488, pages 38–39 (2012)Cite this article

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A rare gene variant has been found that decreases the peptide deposition seen in the brains of people with Alzheimer's disease. The mutation may also slow the normal cognitive decline that occurs with age. See Letter p.96

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Figure 1: Amyloid precursor protein and Alzheimer's disease.

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Author information

Authors and Affiliations

  1. Bart De Strooper and Thierry Voet are in the Center for Human Genetics and Leuven Research Institute for Neurodegenerative Disorders, KU Leuven, 3000 Leuven, Belgium.,

    Bart De Strooper & Thierry Voet

  2. B.D.S. is also at the VIB Center for the Biology of Disease, Leuven.,

    Bart De Strooper

Authors
  1. Bart De Strooper
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  2. Thierry Voet
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Correspondence to Bart De Strooper.

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Competing interests

B.D.S. is a consultant for Janssen Pharmaceutica, Beerse; Envivo Pharmaceuticals, Boston; and Remynd NV, Leuven. He also receives research funding from Janssen Pharmaceutica, Beerse.

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De Strooper, B., Voet, T. A protective mutation. Nature 488, 38–39 (2012). https://doi.org/10.1038/488038a

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