Do you find it difficult to overcome an irrational fear? Blame it on the specific neural circuits hardwired in the brain that control fear recognition, and fear renewal even when fear has seemingly been overcome.
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References
Davis, M. Annu. Rev. Neurosci. 15, 353–375 (1992).
Herry, C. et al. Nature 454, 600–606 (2008).
Likhtik, E., Popa, D., Apergis-Schoute, J., Fidacaro, G. A. Jr & Paré, D. Nature 454, 642–645 (2008).
Pavlov, I. P. Conditioned Reflexes (Dover, 1927).
Rescorla, R. A. Annu. Rev. Neurosci. 11, 329–352 (1988).
Sah, P., Faber, E. S. L., Lopez de Armentia, M. & Power, J. Physiol. Rev. 83, 803–834 (2003).
Falls, W. A., Miserendino, M. J. & Davis, M. J. Neurosci. 12, 854–863 (1992).
Quirk, G. J., Repa, J. C. & LeDoux, J. E. Neuron 15, 1029–1039 (1995).
Collins, D. R. & Paré, D. Learn. Mem. 7, 97–103 (2000).
Delaney, A. J. & Sah, P. J. Neurophysiol. 86, 717–723 (2001).
McDonald, A. J., Mascagni, F. & Guo, L. Neuroscience 71, 55–75 (1996).
Paré, D., Quirk, G. J. & Ledoux, J. E. J. Neurophysiol. 92, 1–9 (2004).
Quirk, G. J., Likhtik, E., Pelletier, J. G. & Paré, D. J. Neurosci. 23, 8800–8807 (2003).
Woodruff, A. R. & Sah, P. J. Neurophysiol. 98, 2956–2961 (2007).
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Sah, P., Westbrook, R. The circuit of fear. Nature 454, 589–590 (2008). https://doi.org/10.1038/454589a
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DOI: https://doi.org/10.1038/454589a
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