Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Diabetes

Fat in all the wrong places

Nature volume 415, pages 268–269 (2002)Cite this article

Obesity and a rare, congenital absence of fat cells are associated with damaging levels of fat in various tissues, and diabetes. Leptin helps to remedy these problems by causing oxidation of fatty acids in mitochondria.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Leptin's control of fat in skeletal muscle2.

References

  1. Friedman, J. M. Harvey Lecture 95, 107–136 (1999–2000).

  2. Minokoshi, Y. et al. Nature 415, 339–343 (2002).

    Article  ADS  CAS  PubMed  Google Scholar 

  3. Randle, P. J. Diabetes Metab. Rev. 14, 263–283 (1998).

    Article  CAS  PubMed  Google Scholar 

  4. McGarry, J. D. Science 258, 766–770 (1992).

    Article  ADS  CAS  PubMed  Google Scholar 

  5. Shulman, G. I. J. Clin. Invest. 106, 171–176 (2000).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Unger, R. H., Zhou, Y.-T & Orci, L. Proc. Natl Acad. Sci. USA 96, 2327–2332 (1999).

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  7. Shimomura, I., Hammer, R., Ikemoto, S., Brown, M. & Goldstein, J. Nature 401, 73–76 (1999).

    Article  ADS  CAS  PubMed  Google Scholar 

  8. Shimabukuro, M. et al. Proc. Natl Acad. Sci. USA 94, 4637–4641 (1997).

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  9. Shimabukuro, M., Zhou, Y. T., Levi, M. & Unger, R. H. Proc. Natl Acad. Sci. USA 95, 2498–2502 (1998).

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  10. Kamohara, S., Burcelin, R., Halaas, J. L., Friedman, J. M. & Charron, M. J. Nature 389, 374–377 (1997).

    Article  ADS  CAS  PubMed  Google Scholar 

  11. Pelleymounter, M. A. et al. Science 269, 540–543 (1995).

    Article  ADS  CAS  PubMed  Google Scholar 

  12. McGarry, J. D., Mannaerts, G. P. & Foster, D. W. J. Clin. Invest. 60, 265–270 (1977).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Winder, W. W. & Hardie, D. G. Am. J. Physiol. 277, E1–E10 (1999).

    CAS  PubMed  Google Scholar 

  14. Abu-Elheiga, L., Matzuk, M. M., Abo-Hashema, K. A. H. & Wakil, S. J. Science 291, 2613–2616 (2001).

    Article  ADS  CAS  PubMed  Google Scholar 

  15. Heymsfield, S. et al. J. Am. Med. Assoc. 282, 1568–1575 (1999).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The Howard Hughes Medical Institute, Rockefeller University, 1230 York Avenue, New York, 10021-6399, New York, USA

    Jeffrey Friedman

Authors
  1. Jeffrey Friedman
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jeffrey Friedman.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Friedman, J. Fat in all the wrong places. Nature 415, 268–269 (2002). https://doi.org/10.1038/415268a

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/415268a

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing