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Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression

Nature volume 387, pages 49–55 (1997)Cite this article

Abstract

Normal mammalian growth and development are highly dependent on the regulation of the expression and activity of the Myc family of transcription factors. Mxi1-mediated inhibition of Myc activities requires interaction with mammalian Sln3A or Sin3B proteins, which have been purported to act as scaffolds for additional co-repressor factors. The identification of two such Sin3-associated factors, the nuclear receptor co-repressor (N-CoR) and histone deacetylase (HD1), provides a basis for Mxi1/Sin3-induced transcriptional repression and tumour suppression.

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Author information

Authors and Affiliations

  1. Department of Microbiology and Immunology,

    Lelia Alland, Rebecca Muhle, Harry Hou Jr, Jason Potes, Lynda Chin, Nicole Schreiber-Agus & Ronald A. DePinho

  2. Department of Pediatrics,

    Lelia Alland

  3. Division of Dermatology, Albert Einstein College of Medicine, 1300 Morris Park Avenue C607, Bronx, New York, New York, 10461, USA

    Lynda Chin

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Alland, L., Muhle, R., Hou, H. et al. Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression. Nature 387, 49–55 (1997). https://doi.org/10.1038/387049a0

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