Review
Nature Reviews Molecular Cell Biology 2, 569-586 (August 2001) | doi:10.1038/35085034
Mycobacterium tuberculosis: here today, and here tomorrow
David G. Russell1 About the author
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Abstract
Mycobacterium tuberculosis is a highly successful pathogen that parasitizes the macrophages of its host. Its success can be attributed directly to its ability to manipulate the phagosome that it resides in and to prevent the normal maturation of this organelle into an acidic, hydrolytic compartment. As the macrophage is key to clearing the infection, the interplay between the pathogen and its host cell reflects a constant battle for control.
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Author affiliations
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Microbiology and Immunology, 5173 Veterinary Medical Center, Cornell University, Ithaca, New York 14853, USA.
Email: dgr8@cornell.edu