Nature Cell Biology
3, E67 - E68 (2001)
doi:10.1038/35060140
Spindles cotton on to junctions, APC and EB1Mariann Bienz
Mariann Bienz is in the Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK
mb2@mrc-lmb.cam.ac.uk
Recent work in Drosophila has shown that the adherens junctions of epithelial cells provide a planar cue to orientate mitotic spindles during symmetrical division. This planar cue depends on the function of E-APC and dEB1, homologues of the adenomatous polyposis coli (APC) tumour suppressor and of the microtubule-binding yeast protein Bim1.
|
