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Eph receptors and neural plasticity

Nature Reviews Neuroscience volume 2, pages 205–209 (2001)Cite this article

Abstract

Eph receptor tyrosine kinases are largely known for their involvement in brain development but, as some of these receptor tyrosine kinases are also expressed in adults, their possible role in the mature nervous system has begun to be explored. Evidence for the involvement of Eph receptors in synaptic plasticity, learning and memory is only emerging and needs corroboration. However, it is likely that the actions of Eph kinases in the adult brain will attract significant attention and become a fertile research area, as occurred in the case of the neurotrophins.

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Figure 1: Infusion of ephrin-A5–IgG in DBA/2 mice improves behavioural performance.

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Authors and Affiliations

  1. the Neuroscience Department, Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, 46285, Indiana, USA

    Robert Gerlai

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  1. Robert Gerlai
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Eph receptors

ephrins

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ephrin-A2

EphA3

EphA4

EphB2

MAP2

L1

Src

Fyn

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Gerlai, R. Eph receptors and neural plasticity. Nat Rev Neurosci 2, 205–209 (2001). https://doi.org/10.1038/35058582

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