Nature Cell Biology
3, E49 - E50 (2001)
doi:10.1038/35055158
Geminin bans replication licenceMark Madine
& Ron Laskey
Mark Madine is in the Chromosomal Replication Laboratory,
Imperial Cancer Research Fund, Clare Hall Laboratories, South Mimms
, Hertfordshire, EN6 3LD, UK.
Ron
Laskey is in the Wellcome/CRC Institute, University of Cambridge,
Tennis Court Road, Cambridge, CB2 1QR,
UK.
madinem@icrf.icnet.uk
Recent work has clarified how higher eukaryotic cells 'licence'
DNA replication precisely once per cycle. An inhibitor, geminin, prevents
replication before mitosis by inhibiting the replication factor Cdt1. Degradation
of geminin in anaphase allows Cdt1 to promote binding of MCM proteins, and
hence DNA replication.
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