Abstract
Recent findings on the possibility of disrupting a stable memory after retrieval challenge some of our widely accepted views on memory consolidation. This article comments on the implications of these and earlier findings to our understanding of consolidation, and explores their possible relationship to the idea that retrieval creates a new memory trace, increasing the resistance of older memories to disruption.
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References
McGaugh, J. L. Memory — a century of consolidation. Science 287, 248–251 (2000).
Squire, L. r. Memory and the hippocampus: A synthesis of findings with rats, monkeys and humans. Psychol. Rev. 99, 195–231 (1992).
Nader, K., Schafe, G. E. & LeDoux, J. E. Fear memories require protein synthesis in the amydgala for reconsolidation after retrieval. Nature 406, 722–726 (2000).
Sara, S. J. Retrieval and reconsolidation: toward a neurobiology of remembering. Learn. Mem. 7, 73–84 (2000).
Land, C., Bunsey, M. & Riccio, D. C. Anomalous properties of hippocampal lesion-induced retrograde amnesia. Psychobiology (in the press).
Misanin, J. R., Miller, R. R. & Lewis, D. J. Retrograde amnesia produced by electroconvulsive shock following reactivation of a consolidated memory trace. Science 160, 554–555 (1968).
Mactutus, C. F., Riccio, D. C. & Ferek, J. M. Retrograde amnesia for old (reactivated) memory: Some anomalous characteristics. Science 204, 1319–1320 (1979).
Miller, R. R. & Springer, A. D. Induced recovery of memory in rats following electroconvulsive shock. Physiol. Behav. 8, 645–651 (1972).
Spear, N. E. & Riccio, D. C. Memory: Phenomena and Principles (Allyn & Bacon, Boston, 1994).
Kim, J. J. & Fanselow, M. S. Modality specific retrograde amnesia of fear following hippocampal lesions. Science 256, 675–677 (1992).
Squire, L. R. & Zola-Morgan, S. The medial temporal lobe memory system. Science 253, 1380–1386 (1992).
Zola-Morgan, S. & Squire, L. R. The primate hippocampal formation: Evidence for a time-limited memory storage. Science 250, 288–290 (1992).
Winocur, G. Anterograde and retrograde amnesia in rats with dorsal hippocampal or dorsomedial thalamic lesions. Behav. Brain Res. 38, 145–154 (1990).
Squire, L. R., Cohen, N. J. & Nadel, L. in Memory consolidation (eds Weingartner, H. & Parker, E.) 185–210 (Lawrence Erlbaum Associates, Hillsdale, New Jersey, 1984).
Przybyslawski, J. & Sara, S. J. Reconsolidation of memory after its reactivation. Behav. Brain Res. 84, 24–26 (1997).
Nadel, L. & Moscovitch, M. Memory consolidation, retrograde amnesia and the hippocampal complex. Curr. Opin. Neurobiol. 7, 217–227 (1997).
Nadel, L. & Moscovitch, M. Hippocampal contributions to cortical plasticity. Neuropharmacology 37, 431–439 (1998).
Riccio, D. C., Ackil, J. & Burch-Vernon, A. Forgetting of stimulus attributes: methodological implications for assessing associative phenomena. Psychol. Bull. 112, 433–445 (1992).
Riccio, D. C., Richardson, R. R. & Ebner, D. L. Memory retrieval deficits based upon altered contextual cues: A paradox. Psychol. Bull. 96, 152–165 (1984).
Land. C. & Riccio, D. C. Nonmonotonic changes in the context shift effect over time. Learn. Mot. 29, 280–287 (1998).
Nadel, L. & Willner, J. Context and conditioning: A place for space. Physiol. Psychol. 8, 218–228 (1980).
Phillips, R. G. & LeDoux, J. E. Differential contributions of amygdala and hippocampus to cued and contextual fear conditioning. Behav. Neurosci. 106, 274–285 (1992).
Winocur, G. Hippocampal lesions alter conditioning to conditional and contextual stimuli. Behav. Brain Res. 88, 219–229 (1997).
Maren, S. & Holt, W. The hippocampus and contextual memory retrieval in Pavlovian conditioning. Behav. Brain Res. 110, 97–108 (2000).
Good, M. & Honey, R. C. Conditioning and contextual retrieval in hippocampal rats. Behav. Neurosci. 105, 499–509 (1991).
Gisquet-Verrier, P. & Alexinsky, T. Time-dependent fluctuations of retention performance in an aversively motivated task. Anim. Learn. Behav. 16, 158–166 (1988).
Gisquet-Verrier, P., Dekeyne, A. & Alexinsky, T. Differential effects of several retrieval cues over time: Evidence for time-dependent reorganization of memory. Anim. Learn. Behav. 17, 394–408 (1989).
Woolley, C. S. & McEwen, B. S. Estradiol mediates fluctuation in hippocampal synapse density during the estrus cycle in the adult rat. J. Comp. Neurol. 336, 293–306 (1993).
Gould, E., Reeves, A. J., Graziano, M. S. A. & Gross, C. G. Neurogenesis in the neocortex of adult primates. Science 286, 548–552 (1999).
Smulders, T. V., Sasson, A. D. & DeVoogdt, T. J. Seasonal changes in telencephalon volume in food storing black-capped chickadees. J. Neurobiol. 27, 15–25 (1995).
Clayton, N. S., Reboreda, J. C. & Kacelnik, A. Seasonal changes of hippocampal volume in parasitic cowbirds. Behav. Proc. 41, 236–243 (1997).
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Nadel, L., Land, C. Memory traces revisited. Nat Rev Neurosci 1, 209–212 (2000). https://doi.org/10.1038/35044572
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DOI: https://doi.org/10.1038/35044572
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