Combined efforts of developmental biologists and cancer geneticists have outlined the canonical Wnt/Wingless (Wg) signalling pathway as we currently know it. At the heart of the pathway is the molecule β-catenin/Armadillo. Recent work has shown that the tumour suppressor adenomatous polyposis coli (APC) acts to shuttle β-catenin from the nucleus to the cytoplasm.
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Clevers, H. Armadillo takes the APC shuttle. Nat Cell Biol 2, E177–E178 (2000). https://doi.org/10.1038/35036424
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DOI: https://doi.org/10.1038/35036424
