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Primary structure of Torpedo marmorata chloride channel isolated by expression cloning in Xenopus oocytes

Nature volume 348, pages 510–514 (1990)Cite this article

Abstract

A complementary DNA encoding a voltage-gated chloride channel from Torpedo marmorata electric organ was cloned by expressing hybrid-depleted messenger RNA in Xenopus oocytes. The predicted protein has a sequence of 805 amino acids containing several putative membrane-spanning domains. Expression of the protein in Xenopus oocytes shows that it is sufficient for channel function.

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Authors and Affiliations

  1. Centre for Molecular Neurobiology (ZMNH), Hamburg University, Martinistrasse 52, D-2000, Hamburg, 20, Germany

    Thomas J. Jentsch, Klaus Steinmeyer & Gisela Schwarz

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  1. Thomas J. Jentsch
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  2. Klaus Steinmeyer
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  3. Gisela Schwarz
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Jentsch, T., Steinmeyer, K. & Schwarz, G. Primary structure of Torpedo marmorata chloride channel isolated by expression cloning in Xenopus oocytes. Nature 348, 510–514 (1990). https://doi.org/10.1038/348510a0

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