Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Review Article
  • Published:

The molecular heterogeneity of protein kinase C and its implications for cellular regulation

Nature volume 334, pages 661–665 (1988)Cite this article

Abstract

Protein kinase C is now known to be a large family of proteins, with multiple subspecies that have subtle individual enzymological characteristics. Some members of the family exhibit distinct patterns of tissue expression and intracellular localization; different kinases probably have distinct functions in the processing and modulation of a variety of physiological and pathological responses to external signals.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Nishizuka, Y. Nature 308, 693–697 (1984).

    ADS  CAS  Google Scholar 

  2. Ono, Y. et al. Science 236, 1116–1120 (1987).

    ADS  CAS  PubMed  Google Scholar 

  3. Kikkawa, U. et al. FEBS Lett. 217, 227–231 (1987).

    CAS  PubMed  Google Scholar 

  4. Ono, Y. et al. J. biol Chem. 263, 6927–6932 (1988).

    CAS  PubMed  Google Scholar 

  5. Parker, P. J. et al. Science 233, 853–859 (1986).

    ADS  CAS  PubMed  Google Scholar 

  6. Coussens, L. et al. Science 233, 859–866 (1986).

    ADS  CAS  PubMed  Google Scholar 

  7. Knopf, J. L. et al. Cell 46, 491–502 (1986).

    CAS  PubMed  Google Scholar 

  8. Ono, Y. et al. FEBS Lett. 206, 347–352 (1986).

    CAS  PubMed  Google Scholar 

  9. Kikkawa, U. et al. FEBS Lett. 223, 212–216 (1987).

    CAS  PubMed  Google Scholar 

  10. Ohno, S. et al. Nature 325, 161–166 (1987).

    ADS  CAS  PubMed  Google Scholar 

  11. Kubo, K., Ohno, S. & Suzuki, K. FEBS Lett. 223, 138–142 (1987).

    CAS  PubMed  Google Scholar 

  12. Ohno, S. et al. Biochemistry 27, 2083–2087 (1988).

    CAS  PubMed  Google Scholar 

  13. Ono, Y. et al. Nucleic Acid Res. 16, 5199–5200 (1988).

    CAS  PubMed  Google Scholar 

  14. Ono, Y. et al. FEBS. Lett. 226, 125–128 (1987).

    CAS  PubMed  Google Scholar 

  15. Ohno, S., Akita, Y., Konno, Y., Imajoh, S. & Suzuki, K. Cell 53, 731–741 (1988).

    CAS  PubMed  Google Scholar 

  16. Berg, J. Science 232, 485–487 (1986).

    ADS  CAS  PubMed  Google Scholar 

  17. Hunter, T. & Cooper, J. A. A. Rev. Biochem. 54, 897–930 (1985).

    CAS  Google Scholar 

  18. Kishimoto, A., Kajikawa, N., Shiota, M. & Nishizuka, Y. J. biol. Chem. 258, 1156–1164 (1983).

    CAS  PubMed  Google Scholar 

  19. Nagle, D. S. & Blumberg, P. M. Cancer Lett. 18, 35–50 (1983).

    CAS  PubMed  Google Scholar 

  20. Worley, P. F., Baraban, J. M. & Snyder, S. H. J. Neurosci. 6, 199–207 (1986).

    CAS  PubMed  PubMed Central  Google Scholar 

  21. Brandt, S. J., Niedel, J. E., Bell, R. M. & Young III, W. S. Cell 49, 57–63 (1987).

    CAS  PubMed  Google Scholar 

  22. Wood, J. G., Girard, P. R., Mazzei, G. J. & Kuo, J. F. J. Neurosci. 6, 2571–2577 (1986).

    CAS  PubMed  PubMed Central  Google Scholar 

  23. Shearman, M. S., Naor, Z., Kikkawa, U. & Nishizuka, Y. Biochem. biophys. Res. Commun. 147, 911–919 (1987).

    CAS  PubMed  Google Scholar 

  24. Mochly-Rosen, D., Basbaum, A. J. & Koshland, D. E. Jr. Proc. natl. Acad. Sci. U.S.A. 84, 4660–4664 (1987).

    ADS  CAS  PubMed  PubMed Central  Google Scholar 

  25. Huang, F. L., Yoshida, Y., Nakabayashi, H. & Huang, K.-P. J. biol. Chem. 262, 15714–15720 (1987).

    CAS  PubMed  Google Scholar 

  26. Huang, F. L. et al. Biochem. biophys. Res. Commun. 149, 946–952 (1987).

    CAS  PubMed  Google Scholar 

  27. Kitano, T. et al. J. Neurosci. 7, 1520–1525 (1987).

    CAS  PubMed  PubMed Central  Google Scholar 

  28. Saito, N., Kikkawa, U., Nishizuka, Y. & Tanaka, C. J. Neurosci. 8, 369–382 (1988).

    CAS  PubMed  PubMed Central  Google Scholar 

  29. Kose, A. et al. J. Neurosci. (in the press).

  30. Hashimoto, T. et al. J. Neurosci. 8, 1678–1683 (1988).

    CAS  PubMed  PubMed Central  Google Scholar 

  31. Ase, K. et al. J. Neurosci. (in the press).

  32. Kosaka, Y. et al. Biochem. biophys. Res. Commun. 151, 973–981 (1988).

    CAS  PubMed  Google Scholar 

  33. McCaffrey, P. G. et al. Biochem. biophys. Res. Commun. 146, 140–146 (1987).

    CAS  PubMed  Google Scholar 

  34. Shearman, M. S., Kosaka, Y., Ase, K., Kikkawa, U. & Nishizuka, Y. Biochem. Soc. Trans. 16, 307–308 (1988).

    CAS  Google Scholar 

  35. Hidaka, H. et al. J. biol. Chem. 236, 4523–4526 (1988).

    Google Scholar 

  36. Pelosin, J., Vilgrain, I. & Chambaz, E. M. Biochem. biophys. Res. Commun. 147, 382–391 (1987).

    CAS  PubMed  Google Scholar 

  37. Shearman, M. S. et al. FEBS Lett. 234, 387–391 (1988).

    CAS  PubMed  Google Scholar 

  38. Makowske, M., Ballester, R., Cayre, Y. & Rosen, O. M. J. biol. Chem. 263, 3402–3410 (1988).

    CAS  PubMed  Google Scholar 

  39. Huang, K.-P. Nakabayashi, H. & Huang, F. L. Proc. natn. Acad. Sci. U.S.A. 83, 8535–8539 (1986).

    ADS  CAS  Google Scholar 

  40. Sekiguchi, K., Tsukuda, M., Ogita, K., Kikkawa, U. & Nishizuka, Y. Biochem. biophys. Res. Commun. 145, 797–802 (1987).

    CAS  PubMed  Google Scholar 

  41. Jaken, S. & Kiley, S. C. Proc. natn. Acad. Sci. U.S.A. 84, 4418–4422 (1987).

    ADS  CAS  Google Scholar 

  42. Sekiguchi, K., Tsukuda, M., Ase, K., Kikkawa, U. & Nishizuka, Y. J. Biochem. (Tokyo) 103, 759–765 (1988).

    CAS  PubMed  Google Scholar 

  43. Asaoka, Y. et al. FEBS Lett. 231, 221–224 (1988).

    CAS  PubMed  Google Scholar 

  44. Ido, M., Sekiguchi, S., Kikkawa, U. & Nishizuak, Y. FEBS Lett. 219, 215–218 (1987).

    CAS  PubMed  Google Scholar 

  45. Kikkawa, U. et al. Cold Spring Harbor Symposia on Quant. Biol. 53 (in the press).

  46. Wooten, M. E. & Wrenn, R. W. Biochem. biophys. Res. Commun. 153, 67–73 (1988).

    CAS  PubMed  Google Scholar 

  47. Hansson, A. et al. Biochem. biophys. Res. Commun. 134, 1215–1222 (1986).

    CAS  PubMed  Google Scholar 

  48. Gonzatti-Haces, M. I. & Traugh, J. A. J. biol. Chem. 261, 15266–15272 (1986).

    CAS  PubMed  Google Scholar 

  49. Bazzi, M. D. & Nelsestuen, G. L. Biochemistry 26, 1974–1982 (1987).

    CAS  PubMed  Google Scholar 

  50. Nishizuka, Y. Science 233, 305–312 (1986).

    ADS  CAS  PubMed  Google Scholar 

  51. Krebs, E. G. & Beavo, J. A. A. Rev. Biochem. 48, 923–959 (1979).

    CAS  Google Scholar 

  52. Housey, G. M. et al. Cell 52, 343–354 (1988).

    CAS  PubMed  Google Scholar 

  53. Persons, D. A., Wilkinson, W. O., Bell, R. M. & Finn, O. J. Cell 52, 447–458 (1988).

    CAS  PubMed  Google Scholar 

  54. Connolly, T. M., Lawing, J. F. & Majerus, P. W. Cell 46, 951–958 (1986).

    CAS  PubMed  Google Scholar 

  55. Woods, N. M., Cuthbertson, K. S. R. & Cobbold, R. H. Biochem. J. 246, 619–623 (1987).

    CAS  PubMed  PubMed Central  Google Scholar 

  56. Schlessinger, J. J. Cell Biol. 103, 2067–2072 (1986).

    CAS  PubMed  Google Scholar 

  57. Cantrell, D. A., Davies, A. A. & Crumpton, M. J. Proc. natn. Acad. Sci. U.S.A. 52, 8158–8162 (1985).

    ADS  Google Scholar 

  58. Young, S., Parker, P. J., Ullrich, A. & Stabel, S. Biochem. J. 244, 775–779 (1987).

    CAS  PubMed  PubMed Central  Google Scholar 

  59. Fournier, A. & Murray, A. W. Nature 330, 767–764 (1987).

    ADS  CAS  PubMed  Google Scholar 

  60. Young, S., Rothbard, J. & Parker, P. J. Eur. J. Biochem. 173, 247–252 (1988).

    CAS  PubMed  Google Scholar 

  61. Ase, K., Berry, N., Kikkawa, U., Kishimoto, A. & Nishizuka, Y. FEBS Lett. (in the press).

  62. Coussens, L., Rhee, L., Parker, P. J. & Ullrich, A. DNA 6, 389–394 (1987).

    CAS  PubMed  Google Scholar 

  63. Housey, G. M., O'Brain, C. A., Johnson, M. D., Kirshemeier, P. & Weinstein, I. B. Proc. natn. Acad. Sci. U.S.A. 84, 1065–1069 (1987).

    ADS  CAS  Google Scholar 

  64. Makowske, M., Birnbaum, M. J. Ballester, R. & Rosen, O. M. J. biol. Chem. 261, 13389–13392 (1986).

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biochemistry, Kobe University School of Medicine, Kobe, 650, Japan

    Yasutomi Nishizuka

Authors
  1. Yasutomi Nishizuka
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Nishizuka, Y. The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Nature 334, 661–665 (1988). https://doi.org/10.1038/334661a0

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/334661a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing