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The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens

Nature volume 329, pages 512–518 (1987)Cite this article

Abstract

Most of the polymorphic amino acids of the class I histocompatibility antigen, HLA-A2, are clustered on top of the molecule in a large groove identified as the recognition site for processed foreign antigens. Many residues critical for T-cell recognition of HLA are located in this site, in positions allowing them to serve as ligands to processed antigens. These findings have implications for how the products of the major histocompatibility complex (MHC) recognize foreign antigens.

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References

  1. Zinkernagel, R. M. & Doherty, P. C. Nature 248, 701–702 (1974).

    Article  ADS  CAS  PubMed  Google Scholar 

  2. Klein, J. in Biology of the Mouse Histocompatibility Complex (Springer, Berlin, 1975).

    Book  Google Scholar 

  3. Bach, F. H. & van Rood, J. J. New Engl. J. Med. 295, 806–813 (1976).

    Article  CAS  PubMed  Google Scholar 

  4. Shimonkevitz, R., Kappler, J., Marack, P. & Grey, H. J. exp. Med. 158, 303–316 (1983).

    Article  CAS  PubMed  Google Scholar 

  5. Babbitt, B., Allen, G., Matsueda, E., Haber, E. & Unanue, E. Nature 317, 359–361 (1985).

    Article  ADS  CAS  PubMed  Google Scholar 

  6. Buus, S. et al. Proc. natn. Acad. Sci. U.S.A. 83, 3968–3971 (1986).

    Article  ADS  CAS  Google Scholar 

  7. Guillet, J. G., Lai, M.-Z., Briner, T. J., Smith, J. A. & Gefter, M. L. Nature 324, 260–263 (1986).

    Article  ADS  CAS  PubMed  Google Scholar 

  8. Buus, S., Sette, A., Colon, S. M., Jenis, D. M. & Grey, H. M. Cell 47, 1071–1077 (1986).

    Article  CAS  PubMed  Google Scholar 

  9. Townsend, A. R. M. et al. Cell 44, 959–968 (1986).

    Article  CAS  PubMed  Google Scholar 

  10. Forman, T. Adv. Immun. (in the press).

  11. McDevitt, H. O. & Tyan, M. L. J. exp. Med. 128, 1–11 (1968).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Bjorkman, P. J. et al. Nature 329, 506–512 (1987).

    Article  ADS  CAS  PubMed  Google Scholar 

  13. Wu, T. T. & Kabat, E. J. exp. Med. 132, 211–250 (1970).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Cowan, E. P., Jelachich, M. L., Biddison, W. E. & Coligan, J. E. Immunogenetics 25, 241–250 (1987).

    Article  CAS  PubMed  Google Scholar 

  15. Gussow, D. et al. Immunogeneties 25, 313–322 (1987).

    Article  CAS  Google Scholar 

  16. Immun. Today, Centre page diagram, 13 (Elsevier, Cambridge, U.K.)

  17. Parham, P. Immun. Res. 6, 153–178 (1987).

    Article  CAS  Google Scholar 

  18. Nathenson, S. G., Geliebler, J., Pfaffenbach, G. M. & Zeff, R. A. A. Rev. Immun. 4, 471–502 (1986).

    Article  CAS  Google Scholar 

  19. Biddison, W. E., Ward, F. E., Shearer, G. M. & Shaw, S. J. Immun. 124, 548–552 (1980).

    CAS  PubMed  Google Scholar 

  20. Lopez de Castro, J., Barbosa, J. A., Krangel, M. S., Biro, A. & Strominger, J. L. Immunol. Rev. 85, 149–168 (1985).

    Article  CAS  PubMed  Google Scholar 

  21. Bevan, M. J. Proc. natn. Acad. Sci. U.S.A. 74, 2094–2098 (1977).

    Article  ADS  CAS  Google Scholar 

  22. Kaufman, J. F., Auffray, C., Korman, A. J., Shackelford, D. A. & Strominger, J. L. Cell 36, 1–13 (1984).

    Article  CAS  PubMed  Google Scholar 

  23. Rupp, R., Acha-Orbea, H., Hengartner, H., Zinkernagel, R. & Joho, R. Nature 315, 425–427 (1985).

    Article  ADS  CAS  PubMed  Google Scholar 

  24. Marrack, P. & Kappler, F. Adv. Immun. 38, 1–30 (1986).

    Article  CAS  PubMed  Google Scholar 

  25. Watts, T. H., Gariepy, J., Schoolnik, G. K. & McConnell, H. M. Proc. natn. Acad. Sci. U.S.A. 82, 5480–5484 (1985).

    Article  ADS  CAS  Google Scholar 

  26. Allen, P. M. et al. Nature 327, 713–715 (1987).

    Article  ADS  CAS  PubMed  Google Scholar 

  27. Delisi, C. & Berzofsky, J. A. Proc. natn. Acad. Sci. U.S.A. 82, 7048–7052 (1985).

    Article  ADS  CAS  Google Scholar 

  28. Berkower, I., Buckenmeyer, G. K. & Berzofsky, J. A. J. Immun. 136, 2498–2503 (1986).

    CAS  PubMed  Google Scholar 

  29. Nairn, R., Spengler, M. L., Hoffman, M. D., Solvay, M. J. & Thomas, D. W. J. Immun. 133, 3225–3234 (1984).

    CAS  PubMed  Google Scholar 

  30. Ezquerra, A. et al. J. Immun. 137, 1642–1649 (1986).

    CAS  PubMed  Google Scholar 

  31. Karmann, G. et al. Immunogenetics 22, 35–38 (1985).

    Article  CAS  PubMed  Google Scholar 

  32. Mattson, D. H. et al. Immunogenetics (in the press).

  33. Rojo, S., Aparicio, P., Hansen, J., Choos, S. Y. & Lopez de Castro, J. A. J. Immun. (in the press).

  34. Rojo, S., Aparicio, P., Choo, S. Y., Hansen, J. A. & Lopez de Castro, J. A. J. Immun. 139, 831–836 (1987).

    CAS  PubMed  Google Scholar 

  35. Vega, M. A. et al. Proc. natn. Acad Sci. U.S.A. 82, 7394–7398 (1985).

    Article  ADS  CAS  Google Scholar 

  36. Vega, M. A. et al. J. Immun. 135, 3323–3332 (1985).

    CAS  PubMed  Google Scholar 

  37. Vega, M. A., Bragado, R., Ivanyi, P., Palaez, J. L. & Lopez de Castro, J. A. J. Immun. 137, 3557–3565 (1986).

    CAS  PubMed  Google Scholar 

  38. Nakagawa, M., Zeff, R. A., Geier, S. S., Bluestone, J. A. & Nathenson, S. G. Immunogenetics 24, 381–385 (1986).

    Article  CAS  PubMed  Google Scholar 

  39. Sailer, R. D., Clayberger, C., Lomen, C. E., Krensky, A. M. & Parham, P. J. exp. Med. 166, 283–288 (1987).

    Article  Google Scholar 

  40. Domenech, N., Ezquerra, A., Castano, R. & Lopez de Castro, J. A. J. Immun. (submitted).

  41. Layet, C. et al. J. Immun. 138, 2197–2201 (1987).

    CAS  PubMed  Google Scholar 

  42. Taketani, S., Krangel, M. S., Pious, D. & Strominger, J. L. J. Immun. 131, 2935–2938 (1983).

    CAS  PubMed  Google Scholar 

  43. Holmes, N., Ennis, P., Wan, A. M., Denney, D. W. & Parham, P. J. Immun. 139, 936–941 (1987).

    CAS  PubMed  Google Scholar 

  44. Krangel, M. S., Biddison, W. E. & Strominger, J. L. J. Immun. 130, 1856–1862 (1983).

    CAS  PubMed  Google Scholar 

  45. Cowan, E. P., Jordan, B. R. & Coligan, J. E. J. Immun. 135, 2835–2841 (1985).

    CAS  PubMed  Google Scholar 

  46. Auffray, C. & Novotny, J. hum. Immun. 15, 381–390 (1986).

    Article  CAS  PubMed  Google Scholar 

  47. Yamada, K. M. & Kennedy, D. W. J. cell. Biochem. 28, 99–104 (1985).

    Article  CAS  PubMed  Google Scholar 

  48. Ways, J. P. & Parham, P. Biochem. J. 216, 423–432 (1983).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  49. Hammerling, G. J., Rusch, E., Tada, N., Kimura, S. & Hammerling, U. Proc. natn. Acad. Sci. U.S.A. 79, 4737–4741 (1982).

    Article  ADS  CAS  Google Scholar 

  50. Wan, A. M., Ennis, P., Parham, P. & Holmes, N. J. Immun. 137, 3671–3674 (1986).

    CAS  PubMed  Google Scholar 

  51. Ways, J. P., Lawlor, D. A., Wan, A. M. & Parham, P. Immunogenetics 25, 323–328 (1987).

    Article  CAS  PubMed  Google Scholar 

  52. Parham, P., Androlewicz, M. J., Holmes, N. J. & Rothenberg, B. E. J. biol. Chem. 258, 6179–6186 (1983).

    CAS  PubMed  Google Scholar 

  53. Parham, P., Lutz, P. M. & Cresswell, P. Immunogenetics 25, (in the press).

  54. Santos-Aguado, J., Biro, P. A., Fuhrmann, U., Strominger, J. L. & Barbosa, J. A. Molec. Cell Biol. 7, 982–990 (1987).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  55. Santos-Aguado, J., Barbosa, J. A., Mentzer, S., Burakoff, S., Biro, P. A. & Strominger, J. L. Abstracts, Fifth HLA and H-2 Cloning Workshop, Geneva, Switzerland (1986) and manuscript in preparation.

  56. Maryanski, J. L., Pala, P., Corradin, G., Jordon, B. R. & Cerottini, J.-C. Nature 324, 578–579 (1986).

    Article  ADS  CAS  PubMed  Google Scholar 

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Author information

Author notes

  1. P. J. Bjorkman

    Present address: Department of Medical Microbiology, Stanford University, Stanford, California, 94305, USA

  2. W. S. Bennett

    Present address: Max-Planck-Institute Für Molekulare Genetik, Abteilung Wittmann, D-1000, Berlin, 33, FRG

  3. D. C. Wiley: To whom correspondence should be addressed.

Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Harvard University and Howard Hughes Medical Institute, Harvard University, Cambridge, Massachusetts, 02138, USA

    P. J. Bjorkman, M. A. Saper, B. Samraoui, W. S. Bennett, J. L. Strominger & D. C. Wiley

  2. Department of Medical Microbiology, Stanford University, Stanford, California, 94305, USA

    P. J. Bjorkman

  3. Max-Planck-Institute Für Molekulare Genetik, Abteilung Wittmann, D-1000, Berlin, 33, FRG

    P. J. Bjorkman

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Bjorkman, P., Saper, M., Samraoui, B. et al. The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens. Nature 329, 512–518 (1987). https://doi.org/10.1038/329512a0

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