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A consensus amino-acid sequence repeat in Torpedo and mammalian Ca2+-dependent membrane-binding proteins

Nature volume 320, pages 636–638 (1986)Cite this article

Abstract

A group of calcium-binding proteins which bind to biomembranes has recently been identified in widely different cells and tissues (refs 1–7, reviewed in ref. 8). Three of these proteins (p70, p36 and p32.5) cross-react with antiserum to calelectrin, a Ca2+-binding protein (relative molecular mass 34,000 (34K)) from the ray Torpedo marmorata3,4, giving rise to their designation as calelectrin-related proteins3. We now report that calelectrin, p36 and p32.5 contain a 17-amino-acid consensus sequence which is conserved and present in multiple copies. We suggest that this sequence may be common to other members of this new group of Ca2+-binding proteins and may underlie their unusual mode of combination with biomembranes.

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Authors and Affiliations

  1. Laboratory of Protein Structure, National Institute for Medical Research, Mill Hill, London, NW7 1AA, UK

    Michael J. Geisow, Bret Dash & Tolu Johnson

  2. Abteilung Neurochemie, Max-Planck-Institut für Biophysikalische Chemie, Göttingen, FRG

    Ulrich Fritsche

  3. Imperial Cancer Research Fund, Lincoln's Inn Fields, London, WC2A 3PX, UK

    J. Mark Hexham

Authors
  1. Michael J. Geisow
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  2. Ulrich Fritsche
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  3. J. Mark Hexham
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  4. Bret Dash
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  5. Tolu Johnson
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Geisow, M., Fritsche, U., Hexham, J. et al. A consensus amino-acid sequence repeat in Torpedo and mammalian Ca2+-dependent membrane-binding proteins. Nature 320, 636–638 (1986). https://doi.org/10.1038/320636a0

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