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Genomic diversity correlates with clinical variation in Ph′-negative chronic myeloid leukaemia

Nature volume 320, pages 281–283 (1986)Cite this article

Abstract

The Philadelphia chromosome (Ph′) is found in the blood cells of about 90% of patients with chronic myeloid leukaemia (CML) and usually results from the reciprocal chromosome translocation t(9; 22)1,2. This translocation relocates the proto-oncogene c-abl, normally found on chromosome 9q34, to within the breakpoint cluster region (bcr) on chromosome 22qll (refs 3–8). The juxtaposition of c-abl and the 5′ portion of bcr appears to be the critical genomic event in CML and results in a novel 8-kilobase (kb) fused abl/bcr transcript9,10 and a c-abl-related protein of relative molecular mass 210,000 (ref. 11). About 10% of adult patients diagnosed as CML lack the Ph′ chromosome; they represent a heterogeneous group of disorders which are difficult to diagnose precisely12. We have examined five patients with CML whose leukaemic cells have a normal karyotype. We report here that two of the patients showed the same genomic change as occurs in Ph′-positive CML, but the change resulted from a mechanism other than chromosomal translocation. The remaining three patients showed no genomic rearrangement. This genomic diversity correlated with the clinical differences between the patients.

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Authors and Affiliations

  1. The Cancer Society of New Zealand Cytogenetics Unit, Christchurch Hospital, Christchurch, New Zealand

    Christine M. Morris, Peter H. Fitzgerald & Peter E. Hollings

  2. Molecular Carcinogenesis Laboratory, Department of Biochemistry, University of Otago, Dunedin, New Zealand

    Anthony E. Reeve

  3. Department of Haematology, Christchurch Hospital, Christchurch, New Zealand

    Michael E. J. Beard & David C. Heaton

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  1. Christine M. Morris
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  2. Anthony E. Reeve
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  5. Michael E. J. Beard
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  6. David C. Heaton
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Morris, C., Reeve, A., Fitzgerald, P. et al. Genomic diversity correlates with clinical variation in Ph′-negative chronic myeloid leukaemia. Nature 320, 281–283 (1986). https://doi.org/10.1038/320281a0

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