Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

A third rearranged and expressed gene in a clone of cytotoxic T lymphocytes

Abstract

In addition to the two previously identified genes rearranged and expressed in a cytotoxic T-lymphocyte clone, we have identified a third gene that is also rearranged and expressed in the same clone. This new gene shows clonal diversity, codes for a polypeptide chain that contains immunoglobulin-like variable and constant domains, carries potential N-glycosylation sites and is a particularly attractive candidate for the gene that encodes the α-subunit of the heterodimeric antigen receptor of this T-cell clone.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Jensenius, J. C. & Williams, A. F. Nature 300, 583–588 (1982).

    Article  ADS  CAS  PubMed  Google Scholar 

  2. Kindred, B. & Shreffler, D. C. J. Immun. 109, 940–943 (1972).

    CAS  PubMed  Google Scholar 

  3. Katz, D. H., Hamaoka, T., Dorf, E. D., Maurer, P. H. & Benacerraf, B. J. exp. Med. 138, 734–739 (1973).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Zinkernagel, R. M. & Doherty, P. C. Nature 248, 701–702 (1974).

    Article  ADS  CAS  PubMed  Google Scholar 

  5. Allison, J. P., McIntyre, B. W. & Bloch, D. J. Immun. 129, 2293–2300 (1982).

    CAS  PubMed  Google Scholar 

  6. Meuer, S. C. et al. J. exp. Med. 157, 705–719 (1983).

    Article  CAS  PubMed  Google Scholar 

  7. Haskins, K. et al. J. exp. Med. 157, 1149–1169 (1983).

    Article  CAS  PubMed  Google Scholar 

  8. Acuto, O. et al. Cell 34, 717–726 (1983).

    Article  CAS  PubMed  Google Scholar 

  9. McIntyre, B. W. & Allison, J. P. Cell 34, 739–746 (1983).

    Article  CAS  PubMed  Google Scholar 

  10. Kappler, J. et al. Cell 35, 295–302 (1983).

    Article  CAS  PubMed  Google Scholar 

  11. Yanagi, Y. et al. Nature 308, 145–149 (1984).

    Article  ADS  CAS  PubMed  Google Scholar 

  12. Hedrick, S. M., Nielsen, E. A., Kavaler, J., Cohen, D. I. & Davis, M. M. Nature 308, 153–158 (1984).

    Article  ADS  CAS  PubMed  Google Scholar 

  13. Saito, H. et al. Nature 309, 757–762 (1984).

    Article  ADS  CAS  PubMed  Google Scholar 

  14. Acuto, O. et al. Proc. natn. Acad. Sci. U.S.A. 81, 3851–3855 (1984).

    Article  ADS  CAS  Google Scholar 

  15. Chien, Y., Gascoigne, N. R. J., Kavaler, J., Lee, N. E. & Davis, M. M. Nature 309, 322–326 (1984).

    Article  ADS  CAS  PubMed  Google Scholar 

  16. Gascoigne, N. R. J., Chien, Y., Becker, D. M., Kavaler, J. & Davis, M. M. Nature 310, 387–391 (1984).

    Article  ADS  CAS  PubMed  Google Scholar 

  17. Siu, G. et al. Cell 37, 393–401 (1984).

    Article  CAS  PubMed  Google Scholar 

  18. Malissen, M. et al. Cell 37, 1101–1110 (1984).

    Article  CAS  PubMed  Google Scholar 

  19. Kavaler, J., Davis, M. M. & Chien, Y. Nature 310, 421–423 (1984).

    Article  ADS  CAS  PubMed  Google Scholar 

  20. Siu, G. et al. Nature 311, 344–350 (1984).

    Article  ADS  CAS  PubMed  Google Scholar 

  21. Kranz, D. M., Sherman, D. H., Sitkovsky, M. V., Pasternack, M. S. & Eisen, H. N. Proc. natn. Acad. Sci. U.S.A. 81, 573–577 (1984).

    Article  ADS  CAS  Google Scholar 

  22. Southern, E. J. molec. Biol. 98, 503–517 (1975).

    Article  CAS  PubMed  Google Scholar 

  23. Thomas, P. S. Meth. Enzym. 100, 255–266 (1983).

    Article  CAS  PubMed  Google Scholar 

  24. Maxam, A. M. & Gilbert, W. Meth. Enzym. 65, 499–560 (1980).

    Article  CAS  PubMed  Google Scholar 

  25. Blobel, G. & Dobberstein, B. J. Cell Biol. 67, 835–851 (1975).

    Article  CAS  PubMed  Google Scholar 

  26. Kabat, E. A., Wu, T. T., Bilofsky, H., Reid-Miller, M. & Perry, H. Sequences of Proteins of Immunological Interest (NIH, Bethesda, 1983).

    Google Scholar 

  27. Von Boehmer, H., Haas, W. & Jerne, N. K. Proc. natn. Acad. Sci. U.S.A. 75, 2439–2442 (1978).

    Article  ADS  CAS  Google Scholar 

  28. Blanden, R. V. & Ada, G. L. Scand. J. Immun. 7, 181–190 (1978).

    Article  CAS  Google Scholar 

  29. Langman, R. E. Rev. Physiol. Biochem. Pharmac. 81, 1–37 (1978).

    Article  CAS  Google Scholar 

  30. Zinkernagel, R. M. et al. J. exp. Med. 147, 882–896 (1978).

    Article  CAS  PubMed  Google Scholar 

  31. Cohn, M. & Epstein, R. E. Cell. Immun. 39, 125–153 (1978).

    Article  CAS  Google Scholar 

  32. Janeway, C. A. Jr, Wigzell, H. & Binz, H. Scand. J. Immun. 5, 993–1001 (1976).

    Article  CAS  Google Scholar 

  33. Matzinger, P. Nature 292, 497–501 (1981).

    Article  ADS  CAS  PubMed  Google Scholar 

  34. Hunig, T. R. & Bevan, M. J. J. exp. Med. 155, 111–125 (1982).

    Article  CAS  PubMed  Google Scholar 

  35. Hedrick, S. M. et al. Cell 30, 141–152 (1982).

    Article  CAS  PubMed  Google Scholar 

  36. Kappler, J. W., Skidmore, B., White, J. & Marrack, P. J. exp. Med. 153, 1198–1214 (1981).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Saito, H., Kranz, D., Takagaki, Y. et al. A third rearranged and expressed gene in a clone of cytotoxic T lymphocytes. Nature 312, 36–40 (1984). https://doi.org/10.1038/312036a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/312036a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing