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X–chromosome inactivation during differentiation of female teratocarcinoma stem cells in vitro

Nature volume 271, pages 329–333 (1978)Cite this article

Abstract

Evidence is presented that both X chromosomes are genetically active in clonal cultures of undifferentiated female mouse teratocarcinoma stem cells derived from a spontaneous ovarian tumour. As the cells differentiate in vitro one of the X chromosomes becomes inactivated.

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Author notes

  1. Shaul Yatziv

    Present address: Department of Pediatrics, Hebrew University, Hadassah Medical Center, Jerusalem, Israel

Authors and Affiliations

  1. Department of Anatomy and Cancer Research Institute, University of California, San Francisco, California, 94143

    Gail R. Martin

  2. Departments of Pediatrics and of Biochemistry and Biophysics, University of California, San Francisco

    Charles J. Epstein, Bruce Travis, Georgianne Tucker & Shaul Yatziv

  3. Departments of Medicine and of Biochemistry and Biophysics, University of California, San Francisco

    David W. Martin Jr, Shirley Clift & Sara Cohen

Authors
  1. Gail R. Martin
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  2. Charles J. Epstein
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  3. Bruce Travis
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  4. Georgianne Tucker
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  5. Shaul Yatziv
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  6. David W. Martin Jr
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  7. Shirley Clift
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  8. Sara Cohen
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Martin, G., Epstein, C., Travis, B. et al. X–chromosome inactivation during differentiation of female teratocarcinoma stem cells in vitro. Nature 271, 329–333 (1978). https://doi.org/10.1038/271329a0

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