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Mast cell histamine and cell dehydration thirst

Nature volume 267, pages 250–252 (1977)Cite this article

Abstract

RAT mast cells, which synthesise and secrete the dipsogenic amines, histamine and 5-hydroxytryptamine (5-HT), are particularly abundant around small blood vessels and are known to be very sensitive to variations in tonicity1. Hypotonic solutions cause their massive degranulation2–4, release amines from their granules5,6 and increase urinary histamine excretion7. Hypertonic solutions cause mast cell degranulation8 and shrinkage9. We report here evidence which suggests that the mast cell is an osmolar receptor and that histamine participates in the afferent link of the drinking behaviour elicited by hypertonic NaCl.

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Author information

Authors and Affiliations

  1. Cátedra de Patología General y Fisiopatología, Institute de Medicina Experimental, Facultad de Medicina, Universidad Central de Venezuela, Apartado de Correos 50587–Sábana, Grande, Caracas, Venezuela

    DANIEL J. GOLDSTEIN

  2. Cátedra de Fisiología, Institute de Medicina Experimental, Facultad de Medicina, Universidad Central de Venezuela, Caracas, Venezuela

    JOSE A. HALPERIN

Authors
  1. DANIEL J. GOLDSTEIN
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  2. JOSE A. HALPERIN
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GOLDSTEIN, D., HALPERIN, J. Mast cell histamine and cell dehydration thirst. Nature 267, 250–252 (1977). https://doi.org/10.1038/267250a0

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