Nature 263, 106 - 109 (09 September 1976); doi:10.1038/263106a0

Rolling hairpin model for replication of parvovirus and linear chromosomal DNA

Peter Tattersall^*† & David C. Ward^‡

^†Imperial Cancer Research Fund, Mill Hill Laboratories, Burtonhole Lane, London NW7 1AD, UK
^‡Departments of Human Genetics and Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut 06510
^*To whom correspondence should be addressed.

A novel, quasicircular scheme is proposed for the replication of parvovirus DNA. Daughter strands are initiated after the copying and rearrangement of a terminal palindromic sequence, a process termed 'hairpin transfer'. Such a process may be involved in the replication of other viruses and host cell DNA.

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