Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Lipopolysaccharide induces C-type virus in short term cultures of BALB/c spleen cells

Abstract

IN certain strains of mice, such as AKR, C-type viruses occur throughout life and can readily be detected by infectivity assays1,2. In other seemingly virus-free strains, C-type viruses can be activated in vivo by X irradiation3,4, chemical carcinogens5, graft-versus-host reactions6 and in vitro by long term cultivation7, by X rays8, halogenated pyrimidine analogues9,10 and mixed lymphocyte reactions6. We report here that lipopolysaccharide, a B-cell mitogen18, induces C-type virus in short term cultures of BALB/c spleen cells.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Gross, L., Natn. Cancer Inst. Mongr., 22, 407 (1966).

    CAS  Google Scholar 

  2. Hartley, J. W., Rowe, W. P., Capps, W. I., and Huebner, R. J., J. Virol., 3, 126 (1969).

    CAS  PubMed  PubMed Central  Google Scholar 

  3. Kaplan, H. S., Cancer Res., 27, 1325 (1967).

    CAS  Google Scholar 

  4. Haran-Ghera, N., Int. J. Cancer, 1, 81 (1966).

    Article  CAS  Google Scholar 

  5. Igel, H. J., Huebner, R. J., Turner, H. C., Kotin, P., and Falk, H. L., Science, 166, 1624 (1969).

    Article  ADS  CAS  Google Scholar 

  6. Hirsch, M. S., Phillips, S. M., Solnik, C., Black, P. H., Schwartz, R. S., and Carpenter, C. B., Proc. natn. Acad. Sci. U.S.A., 69, 1069 (1972).

    Article  ADS  CAS  Google Scholar 

  7. Aaronson, S. A., Hartley, J. W., and Todaro, G. J., Proc. natn. Acad. Sci. U.S.A., 64, 87 (1969).

    Article  ADS  CAS  Google Scholar 

  8. Rowe, W. P., Hartley, J. W., Lander, M. R., Pugh, W. E., and Teich, N., Virology, 46, 866 (1971).

    Article  CAS  Google Scholar 

  9. Lowy, D. R., Rowe, W. P., Teich, N., and Hartley, J. W., Science, 174, 155 (1971).

    Article  ADS  CAS  Google Scholar 

  10. Aaronson, S. A., Todaro, G. J., and Scolnick, E. M., Science, 174, 157 (1971).

    Article  ADS  CAS  Google Scholar 

  11. Schumann, G., Schnebli, H. P., and Dukor, P., Int. Archs Allergy appl. Immun., 45, 331 (1973).

    Article  CAS  Google Scholar 

  12. Wu, A. M., Ting, R. C., Paran, M., and Gallo, R. C., Proc. natn. Acad. Sci. U.S.A., 69, 3820 (1972).

    Article  ADS  CAS  Google Scholar 

  13. Goodman, N. C. and Spiegelman, S., Proc. natn. Acad. Sci. U.S.A., 68, 2203 (1971).

    Article  ADS  CAS  Google Scholar 

  14. Robert, M. S., Smith, R. G., Gallo, R. C., Sarin, P. S., and Abrell, J. W., Science, 176, 798 (1972).

    Article  ADS  CAS  Google Scholar 

  15. Baltimore, D., and Smoler, D., Proc. natn. Acad. Sci. U.S.A., 68, 1507 (1971).

    Article  ADS  CAS  Google Scholar 

  16. McCaffrey, R., Smoler, D. F., and Baltimore, D., Proc. natn. Acad. Sci. U.S.A., 70, 521 (1973).

    Article  ADS  CAS  Google Scholar 

  17. Aaronson, S. A., and Stephenson, J. R., Proc. natn. Acad. Sci. U.S.A., 71, 1957 (1974).

    Article  ADS  CAS  Google Scholar 

  18. Gery, I., Krüger, J., and Spiesel, S. Z., J. Immun., 108, 1088 (1972).

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

MORONI, C., SCHUMANN, G. Lipopolysaccharide induces C-type virus in short term cultures of BALB/c spleen cells. Nature 254, 60–61 (1975). https://doi.org/10.1038/254060a0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1038/254060a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing