Nature 252, 713 - 715 (20 December 1974); doi:10.1038/252713a0

Separation of parathyroid hormone and calcitonin-sensitive cells from non-responsive bone cells

GLENDA WONG & DAVID V. COHN

Calcium Research Laboratory, Veterans Administration Hospital, Kansas City, Missouri 64128 and University of Missouri-Kansas City, School of Dentistry, Kansas City, Missouri 64108 and University of Kansas School of Medicine, Kansas City, Kansas 66103

BONE growth and remodelling depend on resorption and deposition at the local level. The balance between these two processes seems to be modulated by the peptide hormones PTH and calcitonin. Parathyroid hormone (PTH) has been shown to induce bone resorption both in vivo ¹ and in vitro ², whereas calcitonin (CT) inhibits this process³. Recent studies suggest that both agents act on cellular mechanisms through a second messenger. Thus, it has been demonstrated that exposure of mouse calvaria to PTH or CT can lead to an increase in cyclic AMP content^4,5. In addition, dibutyryl cyclic AMP can by itself induce bone resorption².

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