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Nature Structural Biology  5, 839 - 842 (1998)
doi:10.1038/2280

Mechanics of membrane fusion

Josep Rizo1 & Thomas C. Südhof2

1  Departments of Biochemistry and Pharmacology, the Center for Basic Neuroscience and the Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75235, USA.

2  Department of Molecular Genetics, the Center for Basic Neuroscience and the Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75235, USA.

Correspondence should be addressed to Josep Rizo jose@arnie.swmed.edu or Thomas C. Südhof tsudho@mednet.swmed.edu
A fascinating problem in modern cell biology — how membranes fuse — may be close to a solution. A flurry of recent papers report structural results on proteins that are essential for membrane fusion during exocytosis, providing a starting point from which a mechanistic understanding of membrane fusion can be launched.

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Nature Structural & Molecular Biology
ISSN: 1545-9993
EISSN: 1545-9985
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