Nature Cell Biology
1, E143 - E145 (1999)
doi:10.1038/14094
Biddable deathShigekazu Nagata
Shigekazu Nagata is in the Department of Genetics, and CREST, Osaka University Medical School, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan.
Correspondence should be addressed to Shigekazu Nagata nagata@genetic.med.osaka-u.ac.jpMice lacking the pro-apototic protein Bid are resistant to the lethal effects of 'death-factor' signals relayed through Fas. But whereas Bid-deficient hepatocytes are resistant to Fas-mediated apoptosis, thymocytes and embryonal fibroblasts are not. This confirms the cell-type specificity of the Bid-dependent mitochondrial apoptotic pathway.
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