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Where U and I meet

Nature Structural Biology volume 6, pages 605–608 (1999)Cite this article

Abstract

A detailed NMR description of the compact unfolded state of an unstable protein reveals the existence of native and non-native structure under non-denaturing conditions. The structural characterization of this and similar species may provide clues about protein folding mechanisms.

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Figure 1: The ribbon structure of the N-terminal SH3 domain of mammalian Grb2 (3gbq68, with secondary structure elements β2 and β3 adapted to mimic DrkN SH348).
Figure 2: Ribbon diagram of the human Grb2 adaptor protein (1gri)33.
Figure 3: Hypothetical reaction coordinate diagram for the folding reaction of a small monomeric protein.

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Acknowledgements

The insights of O. Bilsel, C.R. Matthews, V. Smith, and J. Zitzewitz are gratefully acknowledged.

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Authors and Affiliations

  1. the Chemistry Department, Pennsylvania State University, University Park, 16802, Pennsylvania, USA

    Juliette T.J. Lecomte & Christopher J. Falzone

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  1. Juliette T.J. Lecomte
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  2. Christopher J. Falzone
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Correspondence to Juliette T.J. Lecomte.

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Lecomte, J., Falzone, C. Where U and I meet. Nat Struct Mol Biol 6, 605–608 (1999). https://doi.org/10.1038/10643

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