Nature Cell Biology
1, E37 - E38 (1999)
doi:10.1038/10030
Cholesterol: stuck in trafficSushmita Mukherjee
& Frederick R. Maxfield
Sushmita Mukherjee and Frederick R. Maxfield are at the
Department of Biochemistry, Weill Medical College of Cornell University,
1300 York Avenue, New York, New York 10021
, USA.
Correspondence should be addressed to Frederick R. Maxfield frmaxfie@mail.med.cornell.eduNiemann−Pick type C is a genetic disorder thought to be partly characterized
by a defect in cholesterol storage in lysosomes. New findings show that in
fact cholesterol accumulates in late endosomes, and this accumulation leads
to the redistribution of membrane proteins.
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