Abstract
Immunosuppressive therapy is commonly used in the management of autoimmune disorders. As marrow-derived lymphocytes appear to play a key role in these diseases, lymphoid ablation followed by replacement with autologous or allogeneic stem cells may be a therapeutic option. We report a 5-year-old boy with severe Evans syndrome which consists of immune thrombocytopenia and Coombs-positive hemolytic anemia. He was rendered into complete remission with marrow ablation followed by rescue with an HLA-identical sibling cord blood transplant. He unexpectedly died 9 months following transplant from acute hepatic failure of unknown etiology.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Raetz, E., Beatty, P. & Adams, R. Treatment of severe Evans syndrome with an allogeneic cord blood transplant. Bone Marrow Transplant 20, 427–429 (1997). https://doi.org/10.1038/sj.bmt.1700907
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/sj.bmt.1700907
Keywords
This article is cited by
-
The contribution of hematopoietic stem cells to beta-cell replacement
Current Diabetes Reports (2009)
-
Haematopoietic SCT in autoimmune diseases in children: rationale and new perspectives
Bone Marrow Transplantation (2008)
-
Split chimerism may be enough to cure Evans syndrome
Bone Marrow Transplantation (2006)
-
Treatment of severe autoimmune disease by stem-cell transplantation
Nature (2005)
-
Refractory Evans' syndrome treated with allogeneic SCT followed by DLI. Demonstration of a graft-versus-autoimmunity effect
Bone Marrow Transplantation (2003)