A new study suggests that stimulating TGF-β production protects against atherosclerosis (1067–1073). But other studies have shown that TGF-β overproduction can cause tissue fibrosis.
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References
Grainger, D.J., Witchell, C.M. & Metcalfe, J.C. Tamoxifen elevates transforming growth factor-β and suppresses diet-induced formation of lipid lesions in mouse aorta. Nature Med. 1, 1067–1073. (1995).
Sporn, M.B. & Roberts, A.B. A major advance in the use of growth factors to enhance wound healing. J. clin. Invest. 92, 2565–2566. (1993).
Beck, L.S. et al. One systemic administration of transforming growth factor-β1 reverses age- or glucocorticoid-impaired wound healing. J. clin. Invest 92, 2841–2849. (1993).
Wahl, S.M. Transforming growth factor β: The good, the bad, and the ugly. J. exp. Med. 180, 1587–1590. (1994).
Border, W.A. & Noble, N.A. Transforming growth factor β in tissue fibrosis. New Engl. J. Med. 331, 1286–1292. (1994).
Kadin, M.E. et al. Loss of receptors for transforming growth factor β in human T-cell malignancies. Proc. natn. Acad. Sd. U.SA. 92, 6002–6006. (1994).
Markowitz, S. et al. Inactivation of the type II TGF-β receptor in colon cancer cells with microsatellite instability. Science 268, 1336–1338. (1995).
Kojima, S., Harpel, P.C. & Rifkin, D.B. Lipoprotein (a) inhibits the generation of transforming growth factor β: An endogenous inhibitor of smooth muscle cell migration. J. Cell Biol. 113, 1439–1445. (1991).
Ross, R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 362, 801–809. (1993).
Grainger, D.J. et al. The serum concentration of active transforming growth factor-β is severely depressed in advanced atherosclerosis. Nature Med. 1, 74–79. (1995).
Dickson, K., Philip, A., Warshawsky, H., O'Connor-McCourt, M. & Bergeron, J.J.M. Specific binding of endocrine transforming growth factor-βl to vascular endothelium. J. clin. Invest. 95, 2539–2554. (1995).
Nikol, S. et al. Expression of transforming growth factor-β1 is increased in human vascular restenosis lesions. J. clin. Invest. 90, 1582–1592. (1992).
Wolf, Y.G., Rasmussen, L.M. & Ruoslahti, E. Antibodies against transforming growth factor-βl suppress intimal hyperplasia in a rat model. J. clin. Invest. 93, 1172–1178. (1994).
Nabel, E.G. et al. Direct transfer of transforming growth factor β1 gene into arteries stimulates fi-brocellular hyperplasia. Proc. natn. Acad. Sd. U.SA. 90, 10759–10763. (1993).
Zugmaier, G. et al. Transforming growth factor β1 induces cachexia and systemic fibrosis without an antitumor effect in nude mice. Cancer Res. 51, 3590–3594. (1991).
Anscher, M.S. et al. Transforming growth factor β as a predictor of liver and lung fibrosis after au-tologous bone marrow transplantation for advanced breast cancer. New Engl. J. Med. 328, 1592–1598. (1993).
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Border, W., Noble, N. Targeting TGF–β for treatment of disease. Nat Med 1, 1000–1001 (1995). https://doi.org/10.1038/nm1095-1000
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DOI: https://doi.org/10.1038/nm1095-1000
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