Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Commentary
  • Published:

Genomic profiling to promote a healthy lifestyle: not ready for prime time

Genomic profiling has the potential to usher in a revolution of personalized healthcare and disease prevention. But evidence to support genomic profiling is inconsistent, and data on the health outcome benefits based on such testing are lacking. For genomic profiling to become valid and useful, well designed epidemiologic studies and thorough clinical evaluations of recommended interventions based on genotype are required.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Collins, F.S. N. Engl. J. Med. 341, 28–37 (1999).

    Article  CAS  Google Scholar 

  2. Roses, A.D. Nature 405, 857–865 (2000).

    Article  CAS  Google Scholar 

  3. Ioannidis, J.P.A., Ntzani, E.E., Trikalinos, T.A. & Contopoulos-Ioannidis, D.G. Nat. Genet. 29, 306–309 (2001).

    Article  CAS  Google Scholar 

  4. Hirschhorn, J.N., Lohmueller, K., Byrne, E. & Hirschhorn, K. Genet. Med. 4, 45–61 (2002).

    Article  CAS  Google Scholar 

  5. Potter, J.D. Nat. Rev. Genet. 2, 142–147 (2001).

    Article  CAS  Google Scholar 

  6. Frosst, P. et al. Nat. Genet. 10, 111–113 (1995).

    Article  CAS  Google Scholar 

  7. van der Put, N.M.J. et al. Lancet 346, 1070–1071 (1995).

    Article  CAS  Google Scholar 

  8. van der Put, N.M.J. et al. Am. J. Hum. Genet. 62, 1044–1051 (1998).

    Article  CAS  Google Scholar 

  9. Deloughery, T.G. et al. Circulation 94, 3074–3078 (1996).

    Article  CAS  Google Scholar 

  10. Kang, S.S. et al. Am. J. Hum. Genet. 48, 536–545 (1991).

    CAS  PubMed  PubMed Central  Google Scholar 

  11. Kluijtmans, L.A. et al. Am. J. Hum. Genet. 58, 35–41 (1996).

    CAS  PubMed  PubMed Central  Google Scholar 

  12. Van Bockxmeer, F.M., Mamotte, C.D., Vasikaran, S.D. & Taylor, R.R. Circulation 95, 21–23 (1997).

    Article  CAS  Google Scholar 

  13. Klerk, M. et al. JAMA 288, 2023–2031 (2002).

    Article  CAS  Google Scholar 

  14. Yang, Q., Khoury, M.J., Botto, L., Friedman, J.M. & Flanders, W.D. Am. J. Hum. Genet. 72, 636–649 (2003).

    Article  CAS  Google Scholar 

  15. Boushey, C.J., Beresford, S.A., Omen, G.S. & Motulsky, A.G. JAMA 274, 1049–1057 (1995).

    Article  CAS  Google Scholar 

  16. Wald, D.S., Law, M. & Morris, J.K. BMJ. 325, 1202–1208 (2002).

    Article  Google Scholar 

  17. Ramachandran, S. et al. JAMA 289, 1251–1257 (2003).

    Article  Google Scholar 

  18. Ames, B.N. Proc. Natl. Acad. Sci. USA 96, 12216–12218 (1999).

    Article  CAS  Google Scholar 

  19. Yates, C.R. et al. Ann. Intern. Med. 126, 608–614 (1997).

    Article  CAS  Google Scholar 

  20. Relling, M.V. et al. J. Natl. Cancer Inst. 91, 2001–2008 (1999).

    Article  CAS  Google Scholar 

  21. Krynetski, E.Y. & Evans, W.E. Am. J. Hum. Genet. 63, 11–16 (1998).

    Article  CAS  Google Scholar 

  22. Krynetski, E.Y. & Evans, W.E. Pharm. Res. 16, 342–349 (1999).

    Article  CAS  Google Scholar 

  23. Higashi, M.K. et al. JAMA 287, 1690–1698 (2002).

    Article  CAS  Google Scholar 

  24. Promoting Safe and Effective Genetic Testing in the United States: Final Report of the Task Force on Genetic Testing (eds. Holtzman, N.A. & Watson, M.S.) (Johns Hopkins University Press, Baltimore, 1997).

  25. Burke, W. et al. Am. J. Epidemiol. 156, 311–318 (2002).

    Article  Google Scholar 

  26. Secretary's Advisory Committee on Genetic Testing. Enhancing the Oversight of Genetic Tests: Recommendations of the SACGT (National Institutes of Health, Bethesda, Maryland, 2000).

  27. Marteau, T.M. & Lerman, C. BMJ 322, 1056–1059 (2001).

    Article  CAS  Google Scholar 

  28. Gollust, S.E., Hull, S.C. & Wilfond, B.S. JAMA 288, 1762–1767 (2002).

    Article  Google Scholar 

  29. Mayor, S. BMJ 326, 354 (2003).

    Article  Google Scholar 

  30. Khoury, M.J. Am. J. Epidemiol. 156, 297–299 (2002).

    Article  Google Scholar 

  31. Little, J. et al. Am. J. Epidemiol. 156, 300–310 (2002).

    Article  Google Scholar 

  32. Dipple, K.M. & McCabe, E.R. Am. J. Hum. Genet. 66, 1729–1735 (2000).

    Article  CAS  Google Scholar 

  33. Beutler, E. Blood 98, 2597–2602 (2001).

    Article  CAS  Google Scholar 

  34. Glazier, A.M., Nadeau, J.H. & Aitman, T.J. Science 598, 2345–2349 (2002).

    Article  Google Scholar 

  35. Pinsky, L., Atkins, D., Ramsey, S. & Burke, W. in Human Genome Epidemiology (eds. Khoury M.K., Little J. & Burke W.) (in the press).

Download references

Acknowledgements

The authors thank M. Gwinn and L. Bradley for their helpful comments on the manuscript.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Susanne B Haga.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Haga, S., Khoury, M. & Burke, W. Genomic profiling to promote a healthy lifestyle: not ready for prime time. Nat Genet 34, 347–350 (2003). https://doi.org/10.1038/ng0803-347

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ng0803-347

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing