Nature Genetics
24, 23 - 25 (2000)
doi:10.1038/71641
Genealogies of mouse inbred strainsJon A. Beck1, 2, Sarah Lloyd1, 2, Majid Hafezparast1, 2, Moyha Lennon-Pierce3, Janan T. Eppig3, Michael F.W. Festing4
& Elizabeth M.C. Fisher21
MRC Prion Unit, Imperial College School of Medicine
(St. Mary's), Norfolk Place, London,
UK. 2
Department of Neurogenetics, Imperial College School
of Medicine (St. Mary's), Norfolk Place, London
, UK. 3
The Jackson Laboratory, Bar Harbor,
Maine, USA. 4
MRC Toxicology Unit, Hodgkin Building, University of
Leicester, Leicester, UK.
Correspondence should be addressed to Elizabeth M.C. Fisher e.fisher@ic.ac.uk.The mouse is a prime organism of choice for modelling human disease. Over
450 inbred strains of mice have been described, providing a wealth of different
genotypes and phenotypes for genetic and other studies. As new strains are
generated and others become extinct, it is useful to review periodically what
strains are available and how they are related to each other, particularly
in the light of available DNA polymorphism data from microsatellite and other
markers. We describe the origins and relationships of inbred mouse strains,
90 years after the generation of the first inbred strain. Given the large
collection of inbred strains available, and that published information on
these strains is incomplete, we propose that all genealogical and genetic
data on inbred strains be submitted to a common electronic database to ensure
this valuable information resource is preserved and used efficiently.
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