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| WARNING: This article category has no been recognised | | | Nature 378, 245 - 248
(16 November 1995); doi:10.1038/378245a0 | 
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The enigma of the natural killer cell Jenny E. Gumperz & Peter Parham
Departments of Structural Biology and Microbiology & Immunology, Sherman Fairchild Building, Stanford University, Stanford, California 94305, USA
Natural killer (NK) cells are controlled by receptors specific for polymorphic determinants of class I molecules of the major histocompatibility complex (MHC). The contrasting properties of NK and cytotoxic T cell (CTL) class I receptors provide complementarity in the cytolytic lymphocyte response to viruses, tumours and transplants. Whereas human NK cell class I receptors consist of immunoglobulin domains, their mouse counterparts resemble C-type lee-tins. This difference may reflect the receptors' diverse and rapidly evolving class I ligands.
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