Review
Nature Reviews Molecular Cell Biology 2, 294-307 (April 2001) | doi:10.1038/35067100
Cbl: many adaptations to regulate protein tyrosine kinases
Christine B. F. Thien1 & Wallace Y. Langdon1 About the authors
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Abstract
Responses to extracellular stimuli are often transduced from cell-surface receptors to protein tyrosine kinases which, when activated, initiate the formation of protein complexes that transmit signals throughout the cell. A prominent component of these complexes is the product of the proto-oncogene c-Cbl, which specifically targets activated protein tyrosine kinases and regulates their signalling. How, then, does this multidomain protein shape the responses generated by these signalling complexes?
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Author affiliations
- Department of Pathology, University of Western Australia , 35 Stirling Highway, Crawley, Western Australia 6009, Australia. Email: wlangdon@cyllene.uwa.edu.au Email: canitbe@cyllene.uwa.edu.au
