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Novel putative receptor tyrosine kinase encoded by the melanoma-inducing Tu locus in Xiphophorus

Nature volume 341, pages 415–421 (1989)Cite this article

Abstract

Malignant melanoma in Xiphophorus fish hybrids is caused by the activity of a dominant oncogene Tu. By combining genetic and molecular approaches, we have isolated the melanoma oncogene. We show that its level of expression correlates with the degree of malignancy of the tumour. The corresponding proto-oncogene is developmentally regulated. The Tu gene codes for a novel receptor tyrosine kinase which is closely related to the receptor for epidermal growth factor.

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References

  1. Friend, S. H., Dryja, T. P. & Weinberg, R. New Engl. J. Med. 318, 618–622 (1988).

    Article  CAS  Google Scholar 

  2. Ponder, B. Nature 335, 400–402 (1988).

    Article  ADS  CAS  Google Scholar 

  3. Knudson, A. G. Cancer Res. 45, 1437–1443 (1985).

    CAS  Google Scholar 

  4. Mechler, B. M., McGinnis, W. & Gehring, W. J. EMBO J. 4, 1551–1557 (1985).

    Article  CAS  Google Scholar 

  5. Jacob, L. et al. Cell 50, 215–225 (1987).

    Article  CAS  Google Scholar 

  6. Gordon, M. Genetics 12, 253–283 (1927).

    CAS  PubMed  PubMed Central  Google Scholar 

  7. Häussler, G. Klin. Wschr. 7, 1561–1562 (1928).

    Article  Google Scholar 

  8. Kosswig, C. Z. Indukt. Abstammungs-Vererbungsl. 47, 150–158 (1928).

    Google Scholar 

  9. Gordon, M. Ann. N.Y. Acad. Sci. 71, 1213–1222 (1958).

    Article  ADS  CAS  Google Scholar 

  10. Atz, J. W. Zoologica 47, 153–181 (1962).

    Google Scholar 

  11. Kosswig, C. Zool. Anz. 175, 21–50 (1965).

    Google Scholar 

  12. Zander, C. D. Mitt. Hamburg. Zool. Inst. 66, 241–271 (1969).

    Google Scholar 

  13. Ahuja, M. R. & Anders, F. Prog. Exp. Tumour Res. 20, 380–397 (1976).

    Article  CAS  Google Scholar 

  14. Morizot, D. C. & Siciliano, M. J. J. Natn. Cancer Inst. 71, 809–813 (1983).

    CAS  Google Scholar 

  15. Ahuja, M. R., Schwab, M. & Anders, F. J. Hered. 71, 403–407 (1980).

    Article  CAS  Google Scholar 

  16. Kallmann, K. D. in Handbook of Genetics (ed. King, I.) 81–132 (Plenum, New York, 1975).

    Book  Google Scholar 

  17. Anders, F., Schartl, M., Barnekow, A. & Anders, A. Adv. Cancer Res. 42, 191–275 (1984).

    Article  CAS  Google Scholar 

  18. Kallmann, K. D. Zoologica 55, 1–16 (1970).

    Google Scholar 

  19. Gordon, M. Genetics 22, 376–392 (1937).

    CAS  PubMed  PubMed Central  Google Scholar 

  20. Kallmann, K. D. & Atz, J. W. Zoologica 51, 107–135 (1966).

    Google Scholar 

  21. Schartl, M. Genetics 119, 679–685 (1988).

    CAS  PubMed  PubMed Central  Google Scholar 

  22. Adam, D., Wittbrodt, J., Telling, A. & Schartl, M. Nucleic Acids Res. 16, 7212 (1988).

    Article  CAS  Google Scholar 

  23. Wakamatsu, Y. Dev. Growth Differ. 22, 731–740 (1980).

    Article  Google Scholar 

  24. Heijne, G. v. J. Molec. Biol. 184, 99–105 (1985).

    Article  Google Scholar 

  25. Heijne, G. v. Nucleic Acids Res. 14, 4683–4690 (1986).

    Article  Google Scholar 

  26. Klein, P., Kanehisa, M. & De Lisi, C. Biochem. Biophys. Acta 815, 468–476 (1985).

    Article  CAS  Google Scholar 

  27. Ullrich, A. et al. Nature 309, 418–425 (1984).

    Article  ADS  CAS  Google Scholar 

  28. Hunter, T. & Cooper, J. A. A. Rev. Biochem. 54, 897–930 (1985).

    Article  CAS  Google Scholar 

  29. Hanks, S. K., Quinn, A. M., & Hunter, T. Science 241, 42–52 (1988).

    Article  ADS  CAS  Google Scholar 

  30. Yarden, Y. & Ullrich, A. A. Rev. Biochem. 57, 443–478 (1988).

    Article  CAS  Google Scholar 

  31. Akiyama, T. et al. Molec. Cell Biol. 8, 1019–1026 (1988).

    Article  CAS  Google Scholar 

  32. King, C. R. et al. EMBO J. 7, 1647–1651 (1988).

    Article  CAS  Google Scholar 

  33. Stern, D. F. & Kamps, M. P. EMBO J. 7, 995–1001 (1988).

    Article  CAS  Google Scholar 

  34. Sprenger, F., Stevens, L. M. & Nüsslein-Vollhard, C. Nature 338, 478–483 (1989).

    Article  ADS  CAS  Google Scholar 

  35. Price, J. V., Clifford, R. J. & Schupbach, T. Cell 56, 1085–1092 (1989).

    Article  CAS  Google Scholar 

  36. Schejter, E. D. & Shilo, B.-Z. Cell 56, 1093–1104 (1989).

    Article  CAS  Google Scholar 

  37. Bornkamm, G. W., Polack, A. & Eick, D. in Cellular Oncogene Activation (ed. Klein, G.) 223–273 (Marcel Dekker, New York, 1988).

    Google Scholar 

  38. Mäueler, W., Raulf, F. & Schartl, M. Oncogene 2, 421–430 (1988).

    PubMed  Google Scholar 

  39. Honegger, A. et al. EMBO J. 7, 3045–3052 (1988).

    Article  CAS  Google Scholar 

  40. Khazaie, K. et al. EMBO J. 7, 3061–3071 (1988).

    Article  CAS  Google Scholar 

  41. Blin, N. & Stafford, W. Nucleic Acids Res. 3, 2303–2308 (1976).

    Article  CAS  Google Scholar 

  42. Vennström, B., Fanshiv, L., Moscovici, C. & Bishop, J. M. J. Virol. 36, 575–585 (1980).

    PubMed  PubMed Central  Google Scholar 

  43. Henikoff, S. Gene 28, 351–359 (1984).

    Article  CAS  Google Scholar 

  44. Dale, R. M. K., McClure, B. A. & Houchins, J. P. Plasmid 13, 31–40 (1985).

    Article  CAS  Google Scholar 

  45. Devereux, J. R. et al. Nucleic Acids Res. 12, 387–395 (1984).

    Article  CAS  Google Scholar 

  46. Lax, I. et al. Molec. Cell Biol. 8, 1970–1978 (1988).

    Article  CAS  Google Scholar 

  47. Tavolga, W. N. Bull. Am. Mus. Nat. His. 94, 161–230 (1949).

    Google Scholar 

  48. Schwab, M. Molec. Gen. Genet 188, 410–417 (1982).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Genzentrum, Max-Planck-Institut fü Biochemie, Am Klopferspitz 18a, D-8033, Martinsried, FRG

    Joachim Wittbrodt, Dieter Adam, Barbara Malitschek, Winfried Mäueler, Friedrich Raulf, Agnes Telling, Scott M. Robertson & Manfred Schartl

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  1. Joachim Wittbrodt
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  2. Dieter Adam
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  3. Barbara Malitschek
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  4. Winfried Mäueler
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  5. Friedrich Raulf
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  6. Agnes Telling
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  7. Scott M. Robertson
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  8. Manfred Schartl
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Wittbrodt, J., Adam, D., Malitschek, B. et al. Novel putative receptor tyrosine kinase encoded by the melanoma-inducing Tu locus in Xiphophorus. Nature 341, 415–421 (1989). https://doi.org/10.1038/341415a0

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