Abstract
We describe a cell in which association of a major histocompatibility complex class I heavy chain with β2-microglobulin is induced by a peptide derived from influenza nucleoprotein. Association of anti-genie peptides with the binding site of class I molecules may be required for correct folding of the heavy chain, association with β2-microglobulin and transport of the antigen-MHC complex to the cell surface.
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Townsend, A., Öhlén, C., Bastin, J. et al. Association of class I major histocompatibility heavy and light chains induced by viral peptides. Nature 340, 443–448 (1989). https://doi.org/10.1038/340443a0
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DOI: https://doi.org/10.1038/340443a0
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