Nature 332, 158 - 161 (10 March 1988); doi:10.1038/332158a0

A synthetic vaccine protects humans against challenge with asexual blood stages of Plasmodium falciparum malaria

Manuel E. Patarroyo^*, Roberto Amador^*, Pedro Clavijo^*, Alberto Moreno^*, Fanny Guzman^*, Pedro Romero^*, Ricardo Tascon^*, Antonio Franco^*, Luis A. Murillo^*, Gabriel Ponton^† & Gustavo Trujillo^†

^* Institute de Inmunologia, Hospital San Juan de Dios, Universidad Nacional de Colombia, Bogota, Colombia SA.
^† Hospital Militar Central de Colombia, Fuerzas Militares de Colombia, Bogota, Colombia S.A.

We have previously shown that a mixture of three synthetic peptides (83.1, 55.1, 35.1), corresponding to fragments of the relative molecular mass 83,000 (83K), 55K and 35K Plasmodium falciparum merozoite-specific proteins, induces protection in Aotus trivirpatus monkeys experimentally infected with P. falciparum ^1,2. Here we describe two polymeric synthetic hybrid proteins based on these peptides that delay or suppress the development of parasitaemia in immunized human volunteers.

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